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TranscriptomicsPSORS2 is due to mutations in CARD14
Psoriasis is a common, immune-mediated, genetic disorder of the skin associated with arthritis in approximately 30% of cases. Previously, we localized PSORS2 (psoriasis susceptibility locus 2) to chromosome 17q25.3-qter following a genome-wide linkage scan in a family of European origin with multipl...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-36387 | biostudies-arrayexpress
TranscriptomicsRare and common variants in CARD14, an epidermal regulator of NF-kappaB, in psoriasis
Psoriasis is a common inflammatory disorder of the skin and other organs. We have determined that mutations in CARD14, encoding an NF-kB activator within skin epidermis, account for PSORS2. Here we describe fifteen additional rare, missense variants in CARD14, their distribution in seven psoriasis c...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-36381 | biostudies-arrayexpress
GenomicsTranscritpomic analyses of CARD14 WT and psoriatic gain-of-function CARD14 E138A mutant over time
Transcritpomic analyses of CARD14 WT and psoriatic gain-of-function CARD14 E138A mutant over time
PRJNA824820 | ENA
TranscriptomicsTranscritpomic analyses of CARD14 WT and psoriatic gain-of-function CARD14 E138A mutant over time
CARD14 gene mutations have been shown to be a causitive factor for psoriasis in human patients. CARD14 signalling is poorly understood and very little is known about how it regulates NF-kB activation. Basic research is therefore required to better understand the mechanisms by which is brings about p...
ORGANISM(S): Homo sapiens 
2024-04-01 | GSE200493 | GEO
GenomicsCARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay
CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay
PRJNA1291766 | ENA
TranscriptomicsPSORS2 is due to mutations in CARD14
Psoriasis is a common, immune-mediated, genetic disorder of the skin associated with arthritis in approximately 30% of cases. Previously, we localized PSORS2 (psoriasis susceptibility locus 2) to chromosome 17q25.3-qter following a genome-wide linkage scan in a family of European origin with multipl...
ORGANISM(S): Homo sapiens 
2012-05-09 | GSE36387 | GEO
TranscriptomicsCARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay
CARD14 is an intracellular NF-κB signaling mediator in the skin, and rare CARD14 variants have been associated with psoriasis and atopic dermatitis. CARD14 is also expressed in intestinal epithelial cells (IEC). However, its function in the intestine remains unknown. We demonstrate here that transge...
ORGANISM(S): Mus musculus 
2025-09-17 | GSE302705 | GEO
GenomicsRegulation of MYC by CARD14 in Human Epithelium is a Determinant of Epidermal Homeostasis and Disease II
Regulation of MYC by CARD14 in Human Epithelium is a Determinant of Epidermal Homeostasis and Disease II
PRJNA1097530 | ENA
UnknownCARD14 expression in dermal endothelial cells in psoriasis.
Not available
S-EPMC4219711 | biostudies-literature
GenomicsRegulation of MYC by CARD14 in Human Epithelium is a Determinant of Epidermal Homeostasis and Disease I
Regulation of MYC by CARD14 in Human Epithelium is a Determinant of Epidermal Homeostasis and Disease I
PRJNA1097507 | ENA
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