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TranscriptomicsAtrial Myxomas Arise From Multipotent Myxoid Cardiac Stem Cells
Myxomas, the most common primary tumor of the heart, usually develop in the atria and consist of a myxoid matrix composed of an acid-mucopolysaccharide-rich stroma with polygonal stromal cells scattered throughout the matrix. These benign tumors, despite their rarity, are a research focus because of...
ORGANISM(S): Homo sapiens 
2020-05-02 | E-MTAB-8642 | biostudies-arrayexpress
TranscriptomicsAtrial Myxomas Arise From Multipotent Myxoid Cardiac Stem Cells
Myxomas, the most common primary tumor of the heart, usually develop in the atria and consist of a myxoid matrix composed of an acid-mucopolysaccharide-rich stroma with polygonal stromal cells scattered throughout the matrix. These benign tumors, despite their rarity, are a research focus because of...
ORGANISM(S): Homo sapiens 
2020-04-01 | E-MTAB-8701 | biostudies-arrayexpress
ProteomicsProteomics of cardiac stromal cells and dermal fibroblasts secretomes
The proteomics characterization of the secretomes as well as the evaluation of their potential to induce cell and tissue responses are widely used strategies. Here are presented the mass spectrometry data of the resident cardiac stromal cells (CRSC) and dermal fibroblasts secretomes, which enables t...
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD026451 | Pride
Dermal fibroblasts Cardiac stromal cells Secretome Lc-ms/ms 
TranscriptomicsHuman iPSC-derived cardiomyocytes under hypoxia/normoxia, treated with bone marrow or cardiac stromal cell extracellular vesicles
RNA-seq was performed on cultured human induced pluripotent cell derived cardiomyocytes (iPSC-CMs). There are four groups, with three samples per group: H1,H2,H3. Negative control. Healthy, normoxic iPSC-CMs D1,D2,D3. Positive control. iPSCs cultured under hypoxic (0-1% O2) for 48h with 2% v/v PBS ...
ORGANISM(S): Homo sapiens 
2024-10-02 | E-MTAB-13966 | biostudies-arrayexpress
TranscriptomicsEstrogen-modulated gene expression in c-kit+ stem cells and CD44+ stromal cells
The recent interest in the role of bone marrow derived endothelial progenitor cells in the benefits of estrogen on cardiovascular health brought us to evaluate if estrogen could affect cardiac repair more broadly by regulating biological processes involved in the functional organization of the bone ...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-9098 | biostudies-arrayexpress
TranscriptomicsExpression data from human fetal cardiac MSCs
The instrinsic regenerative capacity of human fetal cardiac mesenchymal stromal cells (MSCs) has not been fully characterised. Here we demonstrate that we can expand cells with characteristics of cardiovascular progenitor cells from the MSC population of human fetal hearts with only minor fluctuatio...
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-78047 | biostudies-arrayexpress
GenomicsPhenotypic variation between stromal cells differentially impacts engineered cardiac tissue function
Phenotypic variation between stromal cells differentially impacts engineered cardiac tissue function
PRJNA529887 | ENA
GenomicsEndothelium-derived stromal cells contribute to bone marrow niche formation
Comprehensive transcriptional characterization of bone marrow stromal cells by RNA sequencing was performed to determine the molecular properties/signatures of endothelium during niche formation.Here, we identify a rare subset of cells in the human fetal BM that co-express endothelial and stromal ma...
EGAS00001004946 | EGA
TranscriptomicsSingle-cell RNA-seq of Pdgfra+/Sca1+/Cd31- mouse cardiac cells
Adult mice hearts contain a population of resident mesenchymal stem cell (MSC)-like cells called cardiac colony forming units-fibroblast (cCFU-F). The cCFU-F are housed in a population of non-muscle cardiac cells that are Pdgfra+/Sca1+/Cd31- (S+P+ fraction). The goal of this experiment was to profil...
ORGANISM(S): Mus musculus 
2019-03-28 | E-MTAB-7365 | biostudies-arrayexpress
TranscriptomicsCardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment. Loosely defined based on their mesenchymal origin, capacity to adhere to plastic and to secrete extracellular matrix, cardiac fibroblasts have been largely neglected due to hetero...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50531 | biostudies-arrayexpress
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