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TranscriptomicsEffect of Imatinib (1microM, 24 hours) on the microRNA repertoire of chronic myeloid leukemia cell line K562
Using a microarray-based miRNA profiling, we found in a model of chronic myeloid leukemia (CML) that the activity of the oncoprotein BCR-ABL1 regulates the expression of miR-21, a "onco-microRNA" known to be overexpressed in numerous cancers. This relies on the phosphorylation status of ST...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78037 | biostudies-arrayexpress
TranscriptomicsDescription of the microRNA repertoire of leucocytes of patients suffering from atypical myeloproliferative syndromes
Atypical Myeloproliferative Neoplasms (aMPN) share characteristics of MPN and Myelodysplastic Syndromes (MDS). Although anomalies of tyrosine-kinases or proteins involved in cytokine signaling are common in MPN, the pathophysiology of atypical MPN is still elusive. Since deregulation of microRNAs ha...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-75666 | biostudies-arrayexpress
TranscriptomicsGene expression signature of MYB-GATA overexpression plus GATA1 down regulation in undifferentiated or differentiated UT7 cells
Acute basophilic leukemia is a rare subtype of acute myeloblastic leukemia. We recently described a recurrent t(X;6)(p11;q23) translocation occurring in male infants with acute basophilic leukemia, generating a MYB-GATA1 fusion gene. To better understand the role of MYB-GATA1 in the leukemogenesis o...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72913 | biostudies-arrayexpress
TranscriptomicsGenomic assessment of stress in the horse
Thanks to the sequencing of the equine genome in 2009, it is now possible to perform genomic analyses in the horse. Thus, we propose to assess chronic stress by a transcriptomic approach. Two groups of yearlings were maintained in impoverished (n=9) or enriched (n=10) social and sensory conditions. ...
ORGANISM(S): Equus caballus 
2014-06-30 | E-GEOD-50623 | biostudies-arrayexpress
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