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ProteomicsCooking methods affect Advanced Glycation End products and lipid profiles: a randomized cross-over study in healthy subjects
Thermal treatments used in Ultra-Processed Foods (UPFs) lead to advanced glycation end products (AGEs) in food products. UPFs and serum AGEs are both associated with cardiometabolic disease. We explored differential cooking methods as a mechanistic link between UPFs and detrimental health outcomes. ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-24 | PXD059624 | Pride
Human Diet Olink 
MetabolomicsChronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
GenomicsExtracellular Vesicle Signaling in Obesity and Cardiometabolic Disease
Extracellular Vesicle Signaling in Obesity and Cardiometabolic Disease
PRJNA1197579 | ENA
GenomicsExtracellular Vesicle Signaling in Obesity and Cardiometabolic Disease
Extracellular Vesicle Signaling in Obesity and Cardiometabolic Disease
PRJNA1197580 | ENA
MetabolomicsLipid Droplet Inhibitors for Disrupting Lipid Accumulation in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Excessive lipid droplet accumulation in hepatocytes drives the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), often leading to inflammation and fibrosis. As obesity and metabolic syndrome rise, MASLD has become a global concern, spurring research into effective trea...
2025-07-17 | MTBLS12359 | MetaboLights
GenomicsTofacitinib modulates cardiometabolic and immunologic disease markers associated with premature atherosclerosis in SLE
Tofacitinib modulates cardiometabolic and immunologic disease markers associated with premature atherosclerosis in SLE
PRJNA587698 | ENA
Genomics3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease
3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease
PRJNA1301932 | ENA
TranscriptomicsBilberries reduce low-grade inflammation and subacute endotoxemia in individuals with features of metabolic syndrome - microarray/QPCR profiling of dietary effects of bilberries in PBMCs
Obesity and its consequences on cardiometabolic health have been associated to low-grade inflammation. The most diverse source of dietary anti-inflammatory compounds is polyphenols and especially anthocyanins, which are major polyphenols in bilberries (Vaccinium myrtillus). We investigated the effec...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-34145 | biostudies-arrayexpress
ProteomicsGenetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice
Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining the contributions of MMP12...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-05 | PXD046532 | Pride
Matrix metalloproteinase 12 Ldlr-deficient mice Cmd Mmp12 deficiency Proteomics 
GenomicsA mechanistic framework for cardiometabolic and coronary artery disease
A mechanistic framework for cardiometabolic and coronary artery disease
PRJNA781115 | ENA
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