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MetabolomicsPentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-03-22 | MTBLS14090 | MetaboLights
MetabolomicsPentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-04-13 | MTBLS14264 | MetaboLights
MetabolomicsACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation
Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...
2026-04-15 | MTBLS14207 | MetaboLights
TranscriptomicsEffect of a cardiomyocyte-specific Hira conditional knockout on gene expression in the heart
We performed gene expression profiling by microarray using RNA extracted from healthy free wall left ventricle tissues from control and Hira cardiomyocyte-specific conditional knockout mice at 6 weeks of age. Hira is a histone chaperone responsible for replication-independent incorporation of histo...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-71833 | biostudies-arrayexpress
TranscriptomicsmicroRNA-1 negatively regulates expression of the hypertrophy-associated genes calmodulin and Mef2a
Calcium signaling is a central regulator of cardiomyocyte growth and function. Calmodulin is a critical mediator of calcium signals. Because the amount of calmodulin within cardiomyocytes is limiting, precise regulation of calmodulin expression may be an important for regulation of calcium signaling...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-13874 | biostudies-arrayexpress
ProteomicsIsoproterenol-induced cardiac hypertrophy trigger proteome remodeling of mouse cardiomyocytes
Cardiac hypertrophy consists in the enlargement of cardiomyocytes and alteration of the extracellular matrix organization in response to physiological or pathological stress. In pathological hypertrophy ocuurs myocardial damage, loss of cardiomyocytes, fibrosis, inflammation, sarcomere disorganizati...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD013020 | Pride
Hypertrophy Heart Mouse Isoproterenol 
GenomicsG3bp1-miR-1 axis regulates cardiomyocyte hypertrophy
G3bp1-miR-1 axis regulates cardiomyocyte hypertrophy
PRJNA764679 | ENA
TranscriptomicsTranscription profiling of hearts from mice heterozygous for Gata4 mutation (G4D) to investigate the significance of Gata4 in regulating postnatal heart function and in regulating the hypertrophic response of the heart to pathological stress.
An important event in the pathogenesis of heart failure is the development of pathological cardiac hypertrophy. In cultured cardiac cardiomyocytes, the transcription factor Gata4 is required for agonist-induced cardiomyocyte hypertrophy. We hypothesized that in the intact organism Gata4 is an import...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5500 | biostudies-arrayexpress
TranscriptomicsMuRF1 regulation of Fenofibrate’s induction of spontaneous cardiac hypertrophy in vivo.
MuRF1 -/- w/ Fenofibrate treatment leads to the reduction of proteolytic and fibrolytic enzymes, increasing hypertrophy Four strain-matched groups of 3-8 week old mice were investigated: 1) MuRF1 -/- Fenofibrate feed; 2) MuRF1 -/- chow feed; 3) MuRF1 +/+ Fenofibrate feed; 4) MuRF1 +/+ chow feed at...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-68480 | biostudies-arrayexpress
ProteomicsThe β2-subunit of voltage-gated calcium channels inhibits cardiomyocyte hypertrophy through a channel-independent mechanism.
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cav1 pore-forming subunit and the accessory subunits Cav, Cav2 and Cav. Cav is a cytosolic soluble protein that regulates channel trafficking and activity, but it also exerts...
ORGANISM(S): Rattus norvegicus (Rat) Rattus 
2021-09-09 | PXD016483 | Pride
L-type voltage-gated calcium channels  cav-subunit  cardiac hypertrophy  calpain  cardiomyocytes  calpastatin 
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