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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
TranscriptomicsGene expression profiles of mouse ESC cardiomyocyte-specific differentiation
The differentiation to cardiomyocytes is a prerequisite and an important part of heart development. A good understanding of the complicated cardiomyocyte differentiation process benefits cardiogenesis study. Embryonic stem cells (ESCs), cell lines with infinite ability to proliferate and to be diffe...
ORGANISM(S): Mus musculus 
2014-09-25 | E-GEOD-58300 | biostudies-arrayexpress
GenomicsAP-1 activation mediates postnatal cardiomyocyte maturation
AP-1 activation mediates postnatal cardiomyocyte maturation
PRJNA756241 | ENA
ProteomicsCardiomyocyte-Derived HSPB1 Regulates TGF-β1 Maturation and Inhibits Endothelial-to-Mesenchymal Transition in Myocardial Fibrosis after Infarction
Myocardial fibrosis is a major contributor to heart failure after myocardial infarction (MI), primarily driven by endothelial-to-mesenchymal transition (EndoMT). Heat shock protein B1 (HSPB1) has cardioprotective functions, but its role in MI-induced fibrosis remains unclear. Here, we show that card...
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072325 |
GenomicsGDF10 promotes rodent cardiomyocyte maturation during the postnatal period
GDF10 promotes rodent cardiomyocyte maturation during the postnatal period
PRJNA1197527 | ENA
ProteomicsMechanical forces regulate cardiomyocyte myofilament maturation via the VCL-SSH1-CFL axis
Mechanical forces regulate cell behavior and tissue morphogenesis. In particular, cardiac tissues require mechanical stimuli generated by the heartbeat for differentiation and maturation, but the molecular mechanisms underlying these processes remain unclear. Here, we first show that mechanical fo...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-09-06 | PXD014624 | Pride
Heart Rattus norvegicus Cardiac contractility 
GenomicsCompetitive regulation of HOPX transcription governs cardiomyocyte maturation
Competitive regulation of HOPX transcription governs cardiomyocyte maturation
PRJEB52787 | ENA
GenomicsLamins gate nuclear and chromatin structures for cardiomyocyte maturation genes. (CUT&RUN)
Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes. (CUT&RUN)
PRJNA1462735 | ENA
GenomicsLamins gate nuclear and chromatin structures for cardiomyocyte maturation genes. (Hi-C)
Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes. (Hi-C)
PRJNA1462738 | ENA
TranscriptomicsCompetitive regulation of HOPX transcription governs cardiomyocyte maturation
This study establishes the homeodomain only protein, HOPX, as a determinant controlling the molecular switch between cardiomyocyte progenitor and maturation gene programs. This dataset is about time-course CAGE (capped analysis of gene expression) data with genome-wide active transcription footprint...
ORGANISM(S): Homo sapiens 
2022-05-21 | E-MTAB-11719 | biostudies-arrayexpress
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