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TranscriptomicsTranscriptomic single-cell analysis of murine neonatal growth plate with conditional G6PDH deletion
The growth plate controls bone lengthening and provides a template for bone formation. However, chondrocytes function in an avascular milieu and the supply of glucose is important to support the metabolic needs of this highly anabolic structure. Besides being an energetic source, we questioned wheth...
ORGANISM(S): Mus musculus 
2025-01-10 | E-MTAB-14554 | biostudies-arrayexpress
ProteomicsNOVEL ROLE OF FATTY ACID SYNTHASE IN ANGIOGENESIS THROUGH MODULATION OF LYSINE MALONYLATION OF MTOR
The role of fatty acid synthesis (FAS) in endothelial cells (ECs) remains incompletely characterized. In this project, we found that silencing of fatty acid synthase (FASN) impedes vessel sprouting by reducing EC proliferation. Moreover, loss of FASN in ECs impaired angiogenesis in vivo, and FASN bl...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD006503 | Pride
Protein malonylation Fatty acid synthesis Endothelial cell metabolism 
ProteomicsEndothelial metabolic transcriptome plasticity in pathological angiogenesis
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor and choroidal neovascularization (CNV), but little is known about individual EC metabolic transcriptomes. Here, by scRNA-sequencing 28,337 murine choroidal ECs (CECs) and sprouting CNV-ECs, we constructed a t...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD016678 | Pride
Endothelial cells  angiogenesis  choroidal neovascularization  tumor angiogenesis  scrna-seq  transcriptional regulation 
ProteomicsAn integrated approach to profile lung tumor endothelial cell heterogeneity across species and models and to identify angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse) and models (in vivo/vitro) remains poorly inventoried at the single-cell-level. We single-cell RNA-sequenced 56,771 ECs from human/mouse (peri)-tumoral lung and cultured human lung TECs, detected 17 ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD014123 | Pride
Endothelial cells  endothelial heterogeneity  cancer  single cell rna-sequencing  multi-omics  angiogenesis  anti-angiogenic therapy 
UnknownContemporary kidney transplantation has a limited impact on bone microarchitecture.
Not available
S-EPMC8851083 | biostudies-literature
UnknownThe interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis.
Not available
S-EPMC310159 | biostudies-literature
TranscriptomicsVascular endothelial growth factor (VEGF) isoform regulation of early forebrain development
This work was designed to determine the role of the vascular endothelial growth factor A (VEGF) isoforms during early neuroepithelial development in the mammalian central nervous system (CNS), specifically in the forebrain. An emerging model of interdependence between neural and vascular systems in...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-30767 | biostudies-arrayexpress
UnknownDe novo serine synthesis regulates chondrocyte proliferation during bone development and repair.
Not available
S-EPMC8844408 | biostudies-literature
TranscriptomicsTranscription profiling of synectin knock-out mouse primary endothelial cells before and after FGF2 induction
Transcriptional regulatory effects of synectin deletion in murine primary endothelial cells both before and after FGF2 induction.
ORGANISM(S): Mus musculus 
2006-10-01 | E-MEXP-820 | biostudies-arrayexpress
UnknownMOSAIC: a multiscale model of osteogenesis and sprouting angiogenesis with lateral inhibition of endothelial cells.
Not available
S-EPMC3469420 | biostudies-literature
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