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MetabolomicsMetabolomic determinants of carotid atherosclerosis plaque stability
Our objective is to identify the metabolites associated with stability of carotid atheromatous plaques compared to vulnerable plaques, through a metabolomic approach. Eighty consecutive patients with carotid artery stenosis (CAS) who underwent carotid endarterectomy (CEA) according to current guidel...
2025-06-06 | MTBLS12303 | MetaboLights
MetabolomicsHuaban Tongmai Decoction ameliorates carotid artery atherosclerosis by inhibiting ferroptosis via the p53-Parkin mitophagy axis

Background: Carotid artery atherosclerosis (CAS), has exhibited an increasing incidence in recent years. Although Huaban Tongmai decoction (HBTMD) shows considerable therapeutic potential against CAS, the specific molecular mechanisms of its action remain incompletely defined.

Purpose: This...

2026-02-15 | MTBLS13908 | MetaboLights
TranscriptomicsTranscription profiling of rat carotid artery following arteriotomy
Effect of injuring carotid on trascription. Time comparison of rat carotid responses to injury with control.
ORGANISM(S): Rattus norvegicus 
2008-06-10 | E-MEXP-1278 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of stroke-susceptible and asymptomatic human carotid plaques
A microarray analysis of advanced human atherosclerotic carotid artery plaques (equal or over 70% stenosis, NASCET criteria) from radiologically confirmed ipsilateral stroke patients (stroke-susceptible plaques, n=12) compared with carotid plaques collected from clinically asymptomatic patients with...
ORGANISM(S): Homo sapiens 
2011-12-30 | E-MEXP-2257 | biostudies-arrayexpress
TranscriptomicsChanges in miR expression profile carotid plaques induced by acutely induced flow disturbances in apoe-/- mice on a high fat diet.
Atherosclerosis is causally related to disturbed flow through low and oscillatory shear stress. In order to study the miR expression profile in atherosclerotic plaques induced by disturbed flow, partial ligation of the carotid artery was performed. This procedure results acutely in severly reduced b...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-26555 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient
We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asympto...
ORGANISM(S): Homo sapiens 
2006-02-10 | E-MEXP-268 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood from patients with carotid artery stenosis
Identification of novel pathophysiological mechanisms of carotid artery disease at systemic level by studying the gene expression profile of peripheral blood of affected patients with respect to control subjects.
ORGANISM(S): Homo sapiens 
2009-06-30 | E-MEXP-2113 | biostudies-arrayexpress
TranscriptomicsExpression profile of mouse carotid body and adrenal medulla [Affymetrix]
The carotid body is a chemoreceptor that senses decreases in blood oxygen to increase breathing in hypoxia. To look for candidate oxygen sensors in the carotid body, we compared the gene expression of the carotid body to the adrenal medulla, a similar tissue that does not have oxygen sensitivity in ...
ORGANISM(S): Mus musculus 
2015-11-11 | E-GEOD-72133 | biostudies-arrayexpress
TranscriptomicsExpression profile of mouse carotid body and adrenal medulla [RNA-Seq]
The carotid body is a chemoreceptor that senses decreases in blood oxygen to increase breathing in hypoxia. To look for candidate oxygen sensors in the carotid body, we compared the gene expression of the carotid body to the adrenal medulla, a similar tissue that does not have oxygen sensitivity in ...
ORGANISM(S): Mus musculus 
2015-11-11 | E-GEOD-72165 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of human carotid atheroma
The aim of this study was to identify new biomarkers and to investigate pathways involved in the progression of human carotid atheroma. The study was conducted from pieces of carotid endarterectomy collected in 32 hypertensive patients. The samples contained media and neo-intima without adventitia. ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-MTAB-1470 | biostudies-arrayexpress
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