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TranscriptomicsCholesterol lowering depletes smooth muscle cell-derived fibromyocytes and chondromyocytes from atherosclerotic lesions
Study of the effect of low-density lipoprotein (LDL)-lowering therapies on the heterogeneous population of proliferating smooth muscle cells (SMCs) derived from atherosclerotic plaques in an atherosclerotic mouse model by inducing hypercholesterolemia followed by high or low fat diet.
ORGANISM(S): Mus musculus 
2023-12-08 | E-MTAB-12019 | biostudies-arrayexpress
TranscriptomicsMouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations
The single-cell RNA-seq experiment aims to explore the cell-type composition of right coronary artery plaques to provide an overview of human-like atherosclerosis. The PCSK9 transgenic minipigs were subjected to 15 months of HFHC diet (HFHC group f, n=4; m, n=1). At the time of euthanasia, plaque pa...
ORGANISM(S): Sus scrofa 
2025-08-30 | E-MTAB-15464 | biostudies-arrayexpress
TranscriptomicsMeis1 coordinates a network of genes implicated in eye development and microphthalmia
Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degrees. Sporadic and hereditary microphthalmos has been associated to heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identifica...
ORGANISM(S): Mus musculus 
2015-08-27 | E-GEOD-62786 | biostudies-arrayexpress
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