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ProteomicsSuperior Anti-tumor Efficacy of CD4+ CAR-T Cells against Acute Leukemias
While chimeric antigen receptor T-cell (CART) therapy has shown impressive therapeutic efficacy in several hematologic malignancies, primary or secondary treatment failure remains a significant challenge driving investigators to explore opportunities to improve the functionality of CART products. In...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD060508 | Pride
Acute leukemia Antitumor activity Car-t therapy Cd4+ t-cells 
UnknownCombination antiretroviral therapy (cART) restores HIV-1 infection-mediated impairment of JAK-STAT signaling pathway.
Not available
S-EPMC5410242 | biostudies-literature
GenomicsRestoration of LAT signaling through the expression of a novel Adjunctive LAT-Activating CAR (ALA-CART) enhances the antigen-sensitivity and persistence of CAR T cells
Restoration of LAT signaling through the expression of a novel Adjunctive LAT-Activating CAR (ALA-CART) enhances the antigen-sensitivity and persistence of CAR T cells
PRJNA991436 | ENA
TranscriptomicsElevated Serum IL-10 in the Setting of Relapsed B-ALL in Patients Previously Treated with CART
Cytokine release syndrome (CRS) is a life-threatening toxicity of chimeric antigen receptor T-cell therapy (CART) for B-cell acute lymphoblastic leukemia (B-ALL). Lower rates of severe CRS are reported in patients treated with CD22-directed CART (CART22) compared to those treated with CD19-directed ...
ORGANISM(S): Homo sapiens 
2026-07-01 | GSE309375 | GEO
TranscriptomicsRestoration of LAT signaling through the expression of a novel Adjunctive LAT-Activating CAR (ALA-CART) enhances the antigen-sensitivity and persistence of CAR T cells
Chimeric antigen receptor (CAR) T cell therapy have demonstrated remarkable success in treating B-cell malignancies that are refractory to standard therapies; however, preclinical and clinical studies have demonstrated that CAR T cell efficacy is greatly reduced against antigen-low tumors. This was ...
ORGANISM(S): Homo sapiens 
2025-02-04 | GSE236468 | GEO
GenomicsElevated Serum IL-10 in the Setting of Relapsed B-ALL in Patients Previously Treated with CART
Elevated Serum IL-10 in the Setting of Relapsed B-ALL in Patients Previously Treated with CART
PRJNA1335263 | ENA
UnknownConvergent Energy State-Dependent Antagonistic Signaling by Cocaine- and Amphetamine-Regulated Transcript (CART) and Neuropeptide Y (NPY) Modulates the Plasticity of Forebrain Neurons to Regulate Feeding in Zebrafish.
Not available
S-EPMC9962846 | biostudies-literature
UnknownTargeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma.
Not available
S-EPMC11290597 | biostudies-literature
UnknowncART Restores Transient Responsiveness to IFN Type 1 in HIV-Infected Humanized Mice.
Not available
S-EPMC9645216 | biostudies-literature
UnknownAnorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens.
Not available
S-EPMC2042207 | biostudies-literature
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