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TranscriptomicsA nuclear-localized red fluorescence knock-in reporter allele for mouse pancreatic beta-cells
In this study, we generated a novel nuclear-localized red fluorescence knock-in reporter allele (Ins2.Apple) for mouse pancreatic beta-cells. Beta-cells were isolated by FACS from 60-day-old mice, segregated by sex, and RNA-sequencing was performed to assess sex-specific differences in beta-cell gen...
ORGANISM(S): Mus musculus 
2018-12-15 | E-MTAB-6329 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of E15.5 mouse Insm1, Neurod1 and Pax6 knockouts vs Insm1GFP.Cre/+ controls
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1GFP.Cre/+ controls and Insm1 (Insm1GFP.Cre/GFP.Cre), Neurod1 (Insm1GFP.Cre/+; Neurod1LacZ/LacZ), or Pax6 (Insm1GFP.Cre/+; Pax6fl/fl) knockout FACS sorted pancreatic endocrine cells at E15.5. Comparison of Insm1GFP.Cre+/...
ORGANISM(S): Mus musculus 
2021-08-23 | E-MTAB-10262 | biostudies-arrayexpress
TranscriptomicsDynamic Ca2+-dependent transcription links metabolic stress to impaired β-cell identity
Sustained stimulation and elevations in intracellular Ca2+ concentrations due to metabolic stress in pre-diabetic states triggers gene expression changes contributing to the loss of pancreatic β-cell function. To establish a temporal relationship between β-cell stimulation and perturbations in Ca2+...
ORGANISM(S): Mus musculus 
2025-05-22 | E-MTAB-14642 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of human iPSC-derived brain microvascular endothelial cells.
Induced pluripotent stem cells were differentiated to brain microvascular endothelial cells (BMECs) using previously published protocols with minor changes. RNA was collected from purified BMECs after barrier induction and submitted for sequencing.
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-8802 | biostudies-arrayexpress
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