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UnknownTIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1.
Not available
S-EPMC5713500 | biostudies-literature
UnknownLiver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice.
Not available
S-EPMC3970181 | biostudies-literature
TranscriptomicsMicroarray expression profiling of the Igf2 pathway dependency of Trp53 developmental and tumour phenotypes in mice
We tested whether loss of p53 function leads to insulin-like growth factor 2 (IGF2) pathway dependency in vivo in genetically defined mouse models. Unexpectedly we found lethality, due to post-natal lung haemorrhage, occurred in Igf2 paternal null allele female mice (Igf2-p) but only if derived from...
ORGANISM(S): Mus musculus 
2012-06-01 | E-MTAB-1001 | biostudies-arrayexpress
UnknownTriple checkpoint blockade of PD-1, Tim-3, and Lag-3 enhances adoptive T cell immunotherapy in a mouse model of ovarian cancer.
Not available
S-EPMC12501118 | biostudies-literature
UnknownSelumetinib with and without erlotinib in KRAS mutant and KRAS wild-type advanced nonsmall-cell lung cancer.
Not available
S-EPMC4803455 | biostudies-literature
TranscriptomicsCharacterization of human embryonic stem cells with features of neoplastic progression
Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers,...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13995 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for low-grade astrocytoma samples
Copy number analysis of 21 paediatric low-grade astrocytomas identified a discrete copy number gain of 1.9Mb in chromosome band 7q34. The gain was present in 12/14 cerebellar pilocytic astrocytomas. Subsequent analysis of tumour cDNA indentified a novel gene fusion between KIAA1549 and BRAF in these...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14960 | biostudies-arrayexpress
UnknownUstekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial.
Not available
S-EPMC11405276 | biostudies-literature
TranscriptomicsMethylation profiling of human normal somatic tissues, placenta, sperm and an immortalized cell line to identify tissue-specific differentially methylated regions
Genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm and an immortalized cell line using the meDIP technique and a custom oligonucleotide array targetting the vast majority of annotated TSSs and non-promoter CGIs in the human genome.
ORGANISM(S): Homo sapiens 
2008-04-30 | E-TABM-445 | biostudies-arrayexpress
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Not available
S-EPMC4159618 | biostudies-literature
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