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TranscriptomicsSevere alkaline pH stress induces a glucose starvation-related transcriptional response in S. cerevisiae
Alkaline pH stress invokes in S. cerevisiae a potent and fast transcriptional response that includes many genes repressed by glucose. Certain mutants in the glucose-sensing and response pathways, such as those lacking the Snf1 kinase, are sensitive to alkalinization. We show that addition of glucose...
ORGANISM(S): Saccharomyces cerevisiae 
2012-03-02 | E-GEOD-25697 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Rapamycin treatment in yeast cells lacking the Ptc1 protein phosphatase.
We are interested in the study of the already reported sensitivity of yeast cells lacking the type 1 protein phosphatase Ptc1 to the drug rapamycin. In order to carry out our studies, we analyzed the changes in the transcription profile that a short-term incubation with rapamycin (200 ng/mL) has in ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-31 | E-GEOD-11530 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profile of yeast cells lacking the high affinity K+-transport system
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24711 | biostudies-arrayexpress
TranscriptomicsTranscriptomic changes induced in yeast cells by the lack of potassium in the medium
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24712 | biostudies-arrayexpress
TranscriptomicsLack of the pif1 helicase enhances zinc tolerance in S. cerevisiae
The Saccharomyces cerevisiae gene PIF1 encodes a conserved eukaryotic DNA helicase required for both mitochondrial and nuclear DNA integrity. Our previous work revealed that a pif1D strain is tolerant to zinc overload. We demonstrate here that this effect is independent of the Pif1 helicase activity...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-31 | E-GEOD-18411 | biostudies-arrayexpress
TranscriptomicsEffects of depleting the Pkh activity in yeast.
The yeast proteins Pkh1 and Pkh2 are functional counterparts of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Cells carrying simultaneous deletion in both genes, PKH1 and PKH2 are not viable, at least in some genetic backgrounds (Casamayor et al., 1999; Inagaki et al., 1999). C...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-30 | E-GEOD-32623 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to heat shock in Pkh-depleted yeast cells.
The yeast proteins Pkh1 and Pkh2 are functional counterparts of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Cells carrying simultaneous deletion in both genes, PKH1 and PKH2 are not viable, at least in some genetic backgrounds (Casamayor et al., 1999; Inagaki et al., 1999). C...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-30 | E-GEOD-33904 | biostudies-arrayexpress
TranscriptomicsMPA and NQO studies (Sevilla)
RNA polymerases deal with obstacles during transcription elongation that need to be removed. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TCR). To improve our knowledge of transcription elongation and its coupling to TCR, we performed DN...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-29 | E-GEOD-11561 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of yeast cells lacking either the protein phosphatase Ptc6 or Ptc1 and Ptc6, members of the 2C family of protein phosphatases in Saccharomyces cerevisiae.
Type 2C protein phosphatases are encoded in Saccharomyces cerevisiae by several related genes (PTC1-7). To gain insight into the functions attributable to a specific member of this gene family, we have investigated the transcriptional profile of ptc6 mutants under standard growth conditions. We have...
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-19 | E-GEOD-38244 | biostudies-arrayexpress
TranscriptomicsRole of the Glc7 phosphatase regulatory subunit Ypi1 in progression through mitosis
Ypi1 is an essential regulator of the Saccharomyces cerevisiae Glc7 protein phosphatase. Although lack of Ypi1 results in a dramatic blockage in the G2/M cell cycle transition, with abnormally shaped large buds and short spindles, the molecular bases for this phenotype are still obscure. We report h...
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-15 | E-GEOD-23134 | biostudies-arrayexpress
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