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TranscriptomicsIntegrated microRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) includes basal and non-basal subclasses. To further stratify TNBC we determined microRNA (miRNA) and mRNA expression profiles, linked specific miRNA signatures to patient survival and used miRNA/mRNA anti-correlations to identify TNBC subclasses associated with e...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-41970 | biostudies-arrayexpress
TranscriptomicsTranscriptomics profile of myobundles' maturation level
We investigated the transcriptomic profiles of non-stimulated samples from day 14 of differentiation with those from day 0
ORGANISM(S): Homo sapiens 
2025-10-30 | E-MTAB-15933 | biostudies-arrayexpress
TranscriptomicsTWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis
Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity; an EMT/MET axis is critical for metastatic colonization of carcinomas. Unlike epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here we describe the first mi...
ORGANISM(S): Homo sapiens 
2015-02-26 | E-GEOD-54505 | biostudies-arrayexpress
TranscriptomicsTWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis
Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during an active EMT. This experiment includes a total of 12 samples consisting of 2 experimental groups at 2 matching time points (day 4, day 12), each with ...
ORGANISM(S): Homo sapiens 
2015-02-26 | E-GEOD-58560 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [Affymetrix]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41972 | biostudies-arrayexpress
TranscriptomicsContact inhibition controls miR-223 stabilization via p27kip1 expression
The control of cell cycle progression mostly relays on the concerted activity of cyclins, CDKs and CDKs inhibitor. Recent data demonstrated that microRNAs, by regulating the expression of these proteins, contribute to the control of cell cycle progression. Here we provide evidences that the CDK inhi...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-45538 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [RNA-seq]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44052 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [NanoString]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41971 | biostudies-arrayexpress
TranscriptomicsmicroRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer (mouse)
MicroRNA deregulation is frequent in human colorectal cancers (CRCs) but little is known to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b over-expression is triggered in mouse and humans by APC loss, PTEN/PI3K pathway deregulation and by ...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-54177 | biostudies-arrayexpress
TranscriptomicsmicroRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer (Human cell line)
MicroRNA deregulation is frequent in human colorectal cancers (CRCs) but little is known to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b over-expression is triggered in mouse and humans by APC loss, PTEN/PI3K pathway deregulation and by ...
ORGANISM(S): Homo sapiens 
2014-01-17 | E-GEOD-54163 | biostudies-arrayexpress
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