Casey Allison N AN

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Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription

Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...

ORGANISM(S): Mus musculus

2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress

Natural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function

Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...

ORGANISM(S): Mus musculus

2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress

Basin-scale biogeography of marine phytoplankton reflects cellular-scale optimization of metabolism and physiology.

Not available

S-EPMC8782455 | biostudies-literature

SCL006,icSARS CoV Urbani or icSARS Bat SRBD (spike receptor binding domain from the wild type strain Urbani to allow for infection of human and non-human primate cells) infections of the 2B4 clonal derivative of Calu-3 cells - Time course

Purpose of experiment was to compare transcriptomics of 2B4 cells (clonal derivative of Calu-3 cells) infected with either icSARS CoV or the icSARS deltaORF6 mutant. Calu-3 cells were infected with either icSARS CoV or the cSARS Bat SRBD strain at MOI of 1.0. Cells samples were collected at 0, 7, 1...

ORGANISM(S): Homo sapiens

2012-05-06 | E-GEOD-37827 | biostudies-arrayexpress

Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study.

Not available

S-EPMC9757903 | biostudies-literature

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Not available

S-EPMC4580981 | biostudies-literature

The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision.

Not available

S-EPMC9633640 | biostudies-literature

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.