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ProteomicsIdentification of extracellular substrates of apoptotic caspases-3 and -7 cleaved from cell membrane of MDA-MB-231 cells
Investigate whether apoptotic caspases-3 and -7 can cleave membrane-bound proteins from breast cancer MDA-MB-231 cells.
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD061399 | Pride
Apoptotic caspases Gel-based proteomics Shedding Mda-mb-231 cells Degradomics 
UnknownTargeting apoptotic caspases in cancer.
Not available
S-EPMC7155770 | biostudies-literature
UnknownCaspases and their substrates.
Not available
S-EPMC5520456 | biostudies-literature
Genomics
Deep mutational scanning of human caspases
PRJNA622561 | ENA
UnknownCaspases: therapeutic targets in neurologic disease.
Not available
S-EPMC4322071 | biostudies-literature
TranscriptomicsControl of intestinal homeostasis, colitis and colitis-associated colorectal cancer by the inflammatory caspases
Inflammatory caspases are essential effectors of inflammation and cell death. Here, we investigated their roles in colitis and colorectal cancer and report a bimodal regulation of intestinal homeostasis, inflammation and tumorigenesis by caspases-1 and -12. Casp1-/- mice exhibited defects in mucosal...
ORGANISM(S): Mus musculus 
2010-07-01 | GSE20407 | GEO
UnknownSequential unfolding mechanisms of monomeric caspases.
Not available
S-EPMC9881926 | biostudies-literature
UnknownSequential Unfolding Mechanisms of Monomeric Caspases.
Not available
S-EPMC10286309 | biostudies-literature
TranscriptomicsControl of intestinal homeostasis, colitis and colitis-associated colorectal cancer by the inflammatory caspases
Inflammatory caspases are essential effectors of inflammation and cell death. Here, we investigated their roles in colitis and colorectal cancer and report a bimodal regulation of intestinal homeostasis, inflammation and tumorigenesis by caspases-1 and -12. Casp1-/- mice exhibited defects in mucosal...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-20407 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain
Caspases are cysteine-proteases with key roles in the execution phase of apoptosis. Additional cellular activities, unrelated to cell death seem to be influenced by these enzymes. Identification of genes co-regulated with caspases could help to ascertain new biological roles for these proteases.To i...
ORGANISM(S): Homo sapiens 
2014-09-13 | GSE61388 | GEO
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