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ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 6/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Mus musculus (Mouse) synthetic construct 
2025-02-26 | PXD036668 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 3/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD036661 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 1/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD036658 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 4/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-02-26 | PXD036662 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 5/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): synthetic construct 
2025-02-26 | PXD036666 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 2/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD036734 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
TranscriptomicsInteractions of aCPs with Cytosine-rich Polypyrimidine Tracts Enhance Splicing of Cassette Exons
Alternative splicing comprises a robust generator of mammalian transcriptome complexity. Splice site specification and activity are controlled by interactions of cis-acting determinants on a transcript with specific RNA binding proteins. A major subset of these interactions comprises interactions lo...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-71569 | biostudies-arrayexpress
UnknownUse of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.
Not available
S-EPMC3129609 | biostudies-literature
UnknownBrain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice.
Not available
S-EPMC6408736 | biostudies-literature
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
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