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ProteomicsQuality control at the cell surface prevents accumulation of damaged L-type CaV1.2 calcium channels
Defective ion channel turnover and clearance of damaged proteins are associated with aging and neurodegeneration. The L-type CaV1.2 voltage-gated calcium channel mediate depolarization-induced calcium signals in heart and brain. Here, we determined the interaction surface between the L-type calcium ...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) Escherichia coli 
2024-02-16 | PXD044630 | Pride
Calcium channel β-subunit Hotspots Cross-linking mass spectrometry Protein-protein docking Cav1.2 surface expression Actin filaments 
ProteomicsQuality control at the cell surface prevents accumulation of damaged L-type CaV1.2 calcium channels
Defective ion channel turnover and clearance of damaged proteins are associated with aging and neurodegeneration. The L-type CaV1.2 voltage-gated calcium channel mediate depolarization-induced calcium signals in heart and brain. Here, we determined the interaction surface between the L-type calcium ...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) Escherichia coli 
2024-02-16 | PXD044723 | Pride
Calcium channel β-subunit Hotspots Cross-linking mass spectrometry Protein-protein docking Cav1.2 surface expression Actin filaments 
UnknownThe Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels.
Not available
S-EPMC3307476 | biostudies-literature
ProteomicsMapping the interaction surface between CaVβ and actin and its role in calcium channel clearance
Defective ion channel turnover and clearance of damaged proteins are associated with aging and neurodegeneration. The L-type CaV1.2 voltage-gated calcium channel mediate depolarization-induced calcium signals in heart and brain. Here, we determined the interaction surface between the L-type calcium ...
ORGANISM(S): Escherichia coli 
2025-04-09 | PXD053456 | Pride
Calcium channel β-subunit Hotspots Cross-linking mass spectrometry Protein-protein docking Cav1.2 surface expression Actin filaments 
ProteomicsMapping the interaction surface between CaVβ and actin and its role in calcium channel clearance
Defective ion channel turnover and clearance of damaged proteins are associated with aging and neurodegeneration. The L-type CaV1.2 voltage-gated calcium channel mediate depolarization-induced calcium signals in heart and brain. Here, we determined the interaction surface between the L-type calcium ...
ORGANISM(S): Escherichia coli 
2025-04-09 | PXD053481 | Pride
Calcium channel β-subunit Hotspots Cross-linking mass spectrometry Protein-protein docking Cav1.2 surface expression Actin filaments 
UnknownRBM20 Regulates CaV1.2 Surface Expression by Promoting Exon 9* Inclusion of CACNA1C in Neonatal Rat Cardiomyocytes.
Not available
S-EPMC6888234 | biostudies-literature
TranscriptomicsGenomic expression profiling of TNFalpha treated BDC2.5 diabetogenic CD4+ T Cells
Tumor necrosis factor alpha (TNFalpha) plays an important role in immune regulation, inflammation, and autoimmunity. Chronic TNFalpha exposure has been shown to down-modulate T cell responses. In a mouse T cell hybridoma model, TNFalpha attenuated T cell receptor (TCR) signaling. We have confirme...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-10029 | biostudies-arrayexpress
UnknownIdentification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity.
Not available
S-EPMC4813503 | biostudies-literature
UnknownThe PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.
Not available
S-EPMC4303668 | biostudies-literature
UnknownBipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2.
Not available
S-EPMC9535808 | biostudies-literature
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