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ProteomicsExtensive and systematic rewiring of histone post-translational modifications in cancer model systems
Histone post-translational modifications (PTMs) generate a complex combinatorial code that regulate gene expression and nuclear functions, and whose deregulation has been documented in different types of cancers. Therefore, the availability of relevant culture models that can be manipulated and that...
ORGANISM(S): Homo sapiens (Human) 
2018-04-06 | PXD007235 | Pride
Tissue Histone post-translational modifications Cell culture Primary cells 
ProteomicsEpiproteomic Profiling Identifies Histone H4 Hyperacetylation as a Prognostic Marker in Pleural Mesothelioma
Pleural mesothelioma (PM) is an aggressive tumor that arises from mesothelial cells as a consequence of asbestos exposure. Despite recent therapeutic advances, including immune checkpoint inhibitors and multimodal treatment strategies, the prognosis of PM remains poor, with a median overall survival...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD076262 | Pride
Histone post-translational modifications Pleural mesothelioma 
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