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TranscriptomicsThree-dimensional folding and functional organization principles of the Drosophila genome
Chromosomes are the physical realization of genetic information and thus form the basis for its reading, hindering and propagation. Here we present a high-resolution chromosomal contact map derived from a new genome-wide chromosome conformation capture approach (a simplified version of the Hi-C meth...
ORGANISM(S): Drosophila melanogaster 
2012-01-20 | E-GEOD-34453 | biostudies-arrayexpress
TranscriptomicsCooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila
We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species (GSE60428) and HiC analysis in Drosophila melanogaster. We demonstrate an extremely high conservation of Polyc...
ORGANISM(S): Drosophila melanogaster 
2014-10-20 | E-GEOD-61471 | biostudies-arrayexpress
GenomicsCooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila
We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We val...
ORGANISM(S): Drosophila virilis 
2014-10-20 | E-GEOD-60428 | biostudies-arrayexpress
TranscriptomicsChromosome conformation capture on chip (4C) at the Fab7 polycomb response element in the bithorax complex of Drosophila
In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA. Both clusters are repressed by Polycomb group (PcG) proteins. Here, we show that genes of th...
ORGANISM(S): Drosophila melanogaster 
2010-12-31 | E-GEOD-23887 | biostudies-arrayexpress
GenomicsIdentification of new regulators of the three dimensional Polycomb organization by a microscopy-based genome-wide RNAi screen
Polycomb group (PcG) proteins dynamically define cellular identities through epigenetic repression of key developmental genes. PcG target gene repression can be stabilized through the interaction in the nucleus at PcG foci. Here, we report the results of a high-resolution microscopy genome-wide RNAi...
ORGANISM(S): Drosophila melanogaster 
2014-04-03 | E-GEOD-55303 | biostudies-arrayexpress
UnknownThe Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination.
Not available
S-EPMC9368738 | biostudies-literature
UnknownSynthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib.
Not available
S-EPMC7997579 | biostudies-literature
UnknownThe impact of cognitive function deficits and their recovery on functional outcome in subjects affected by ischemic subacute stroke: results from the Italian multicenter longitudinal study CogniReMo.
Not available
S-EPMC10266259 | biostudies-literature
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