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ProteomicsDiscovery proteomics studies for the identification of a protein panel associated with the response to pemetrexed in platinum drug resistant cancer
Pemetrexed is a drug largely used in lung cancer, mesothelioma and proposed in some cases of ovarian cancers, a particularly severe cancer type. In this latest tumor type, therapy relies on debulking surgery and platinum-based chemotherapy. Despite the initial high response rates to platinum drugs, ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007056 | Pride
Platinum drug resistance Lc ms/ms Ovarian cancer Discovery proteomics 
TranscriptomicsPAX5TEL GENE EXPRESSION IN PREBI CELLS - FAZIO G.
In the present study, we investigated PAX5TEL function in transcription processes by transduction of PAX5TEL construct in wild type preBI cells, a primary culture of immature B cells expressing endogenous wild type PAX5 protein.
ORGANISM(S): Mus musculus 
2012-11-13 | E-MEXP-3095 | biostudies-arrayexpress
TranscriptomicsB-ALL relapse analysis
A comparison of RNA expression profiles from leukemic cells of 8 single B-ALL patients at diagnosis and relapse. For all patients, clonality of the blast cells at diagnosis and relapse was demonstrated to be the same (Germano, G., del Giudice, L., Palatron, S., Giarin, E., Cazzaniga, G., Biondi, A.,...
ORGANISM(S): Homo sapiens 
2003-06-13 | GSE416 | GEO
ModelsBesozzi2012 - Oscillatory regimes in the Ras/cAMP/PKA pathway in S.cerevisiae
Besozzi2012 - Oscillatory regimes in the Ras/cAMP/PKA pathway in S.cerevisiae Mechanistic model of the Ras/cAMP/PKA in yeast S.cerevisiae. The Ras/cAMP/PKA pathway plays a major role in the regulation of metabolism, stress resistance and cell cycle progress and is tightly regulated...
2024-09-02 | BIOMD0000000478 | BioModels
UnknownEvaluating the risk of data loss due to particle radiation damage in a DNA data storage system.
Not available
S-EPMC11401870 | biostudies-literature
TranscriptomicsTranscription profiling of human Downs syndrome with acute lymphoblastic pediatric leukemia (DS-ALL) patients
DS-ALL is a highly heterogeneous disease with predominance of an aberrant exp. of CRLF2 cooperating with mutated JAK2; Acute lymphoblastic pediatric leukemia specimens of Down's syndrome are examined for gene expression profiles and specific genetic aberrations. Gene expression profiling and specifi...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-GEOD-17459 | biostudies-arrayexpress
TranscriptomicsNovel PAX5 fusion genes in childhood B-Cell Precursors Acute Lymphoblastic Leukemia
PAX5, a transcription factor essential for B-cell development, has been found as a frequent target of abnormalities in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) cases, showing point mutations, deletions, as well as translocations with several partner genes. We identified four novel PAX...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-MTAB-2416 | biostudies-arrayexpress
GenomicsHomo sapiens
B-ALL relapse analysis
PRJNA84971 | ENA
UnknownTargeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria.
Not available
S-EPMC9966845 | biostudies-literature
UnknownThe Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia.
Not available
S-EPMC3592825 | biostudies-literature
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