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ProteomicsLocking CBL in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukaemia (part2)
Casitas B-lineage lymphoma (CBL) is critical to the negative regulation of receptor protein tyrosine kinases (RTKs). Mutant CBL can act as an adaptor and gain function to cause myeloproliferative diseases. Currently, there is no beneficial treatment available for leukaemia patients with CBL mutation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051179 | Pride
Peptide inhibitor cblock Leukaemia Cbl tyrosine kinase binding domain Casitas b-lineage lymphoma (cbl) 
ProteomicsLocking CBL in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukaemia (part 1)
Casitas B-lineage lymphoma (CBL) is critical to the negative regulation of receptor protein tyrosine kinases (RTKs). Mutant CBL can act as an adaptor and gain function to cause myeloproliferative diseases. Currently, there is no beneficial treatment available for leukaemia patients with CBL mutation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051178 | Pride
Peptide inhibitor cblock Cbl’s tyrosine kinase binding domain Leukaemia Casitas b-lineage lymphoma (cbl) 
TranscriptomicsSNP chip data of MDS
Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic progenitors characterized by ineffective hematopoiesis and high propensity to leukemias. Although a number of gene targets have been identified, in many MDS cases, particular genetic targets are unknown. In this study, we performe...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-15187 | biostudies-arrayexpress
UnknownStructural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.
Not available
S-EPMC2265755 | biostudies-literature
UnknownPeptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain.
Not available
S-EPMC3325325 | biostudies-literature
TranscriptomicsProtein Tyrosine Phosphatase UBASH3B is Overexpressed in Triple-Negative Breast Cancer and Promotes Invasion and Metastasis
Efforts to improve the clinical outcome of highly aggressive triplenegative breast cancer (TNBC) have been hindered by the lack of effective targeted therapies. Hence, it is important to identify the specific gene targets/pathways driving the invasive phenotype to develop more effective therapeutics...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-36693 | biostudies-arrayexpress
UnknownPhosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.
Not available
S-EPMC5916117 | biostudies-literature
UnknownStructural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Not available
S-EPMC3880865 | biostudies-literature
UnknownAutoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b.
Not available
S-EPMC3251137 | biostudies-literature
UnknownCbl controls EGFR fate by regulating early endosome fusion.
Not available
S-EPMC2813709 | biostudies-literature
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