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TranscriptomicsContribution of CBX4 to cumulus oophorus cell phenotype in mice, and attendant effects in cumulus cell cloned embryos
Cumulus oophorus cells play an essential role in oocyte development. CBX4 is a member of the Polycomb complex, which plays a role in regulating cellular differentiation. We used siRNA mediated knockdown of Cbx4 expression followed by Affymetrix array analysis to evaluate the role of CBX4 in cumulus ...
ORGANISM(S): Mus musculus 
2014-04-29 | E-GEOD-46565 | biostudies-arrayexpress
GenomicsCBX4 role in U2OS/MTX300
CBX4 role in U2OS/MTX300
PRJNA590871 | ENA
ProteomicsCBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2
Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a functional cure for the acquired immunodeficiency syndrome (AIDS). To develop more promising latency-reversing agents (LRAs) to efficiently reactivate the latent reservoir which is subsequently eliminated by immune surv...
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD031011 |
GenomicsSafeguarding nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
Safeguarding nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
PRJNA481020 | ENA
GenomicsMaintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
PRJNA515848 | ENA
TranscriptomicsKnockdown and Overexpression of Cbx4 wild type, Cbx4 chromodomain mutant, and Cbx4 sumoylation mutant in human epidermal stem cells
This SuperSeries is composed of the following subset Series: GSE31093: Knockdown and Overexpression of Cbx4 wild type and of a Cbx4 chromodomain mutant in human epidermal stem cells GSE31094: Overexpression of Cbx4 wild type and of a Cbx4 sumoylation mutant in human epidermal stem cells Refer to ind...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-31147 | biostudies-arrayexpress
TranscriptomicsCBX4 role in U2OS/MTX300
In our study, we found that CBX4 was critical to osteosarcoma metastasis.CBX4, also known as polycomb 2 (Pc2), belongs to the CBX protein family, including CBX2, 4, 6, 7, and 8, which has been shown to participate in the polycomb repressive complex 1 (PRC1) and characterized as a transcriptional rep...
ORGANISM(S): Homo sapiens 
2020-02-04 | GSE140763 | GEO
TranscriptomicsSafeguarding nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
Chromobox homolog 4 (CBX4), a component of polycomb repressive complexes 1 (PRC1), plays important roles in the maintenance of cell identity and organism development through epigenetic silencing. However, it remains unclear whether CBX4 regulates the homeostasis of human stem cells. Here, we demonst...
ORGANISM(S): Homo sapiens 
2019-07-13 | GSE117084 | GEO
TranscriptomicsMaintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
CBX4, a component of polycomb repressive complex 1 (PRC1), plays important roles in the maintenance of cell identity and organ development through epigenetic silencing. However, whether CBX4 regulates the homeostasis of human stem cells remains unclear. Here, we demonstrate that CBX4 counteracts hum...
ORGANISM(S): Mus musculus 
2019-01-19 | GSE125320 | GEO
TranscriptomicsKnockdown and Overexpression of Cbx4 wild type and of a Cbx4 chromodomain mutant in human epidermal stem cells
Human epidermal stem cells transit from a slow cycling to an actively proliferating state to contribute to homeostasis. Both stem cell states differ in their cell cycle profiles but must remain guarded from differentiation and senescence. Here we show that Cbx4, a Polycomb Repressive Complex-1 (PRC1...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-31093 | biostudies-arrayexpress
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