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GenomicsComparison of transcriptional changes after CD28/CD3z and 4-1BB/CD3z chimeric antigen receptor ligation
Comparison of transcriptional changes after CD28/CD3z and 4-1BB/CD3z chimeric antigen receptor ligation
PRJNA429804 | ENA
TranscriptomicsComparison of transcriptional changes after CD28/CD3z and 4-1BB/CD3z chimeric antigen receptor ligation
The adoptive transfer of chimeric antigen receptor- (CAR) modified T cells is revolutionizing the treatment of B cell malignancies and has the potential to be applied to other diseases. CARs redirect T cell specificity by linking an antigen recognition domain to T cell signaling modules comprised of...
ORGANISM(S): Homo sapiens 
2018-08-19 | GSE109161 | GEO
ProteomicsAPEX2-based quantitative proteomic study of LAT and CD3z in Jurkat T cells
TCR binding to its ligands induces a cascade of signaling starting by the phosphorylation of immunoreceptor tyrosine-based activation motif (ITAMs) present in the TCR-associated CD3 complex. This is followed by the phosphorylation of proteins including the adaptor LAT, which once phosphorylated inte...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD060106 | Pride
Tcr signaling T lymphocyte Proximity ligation assay 
UnknownCD3Z hypermethylation is associated with severe clinical manifestations in systemic lupus erythematosus and reduces CD3ζ-chain expression in T cells.
Not available
S-EPMC5850282 | biostudies-literature
UnknownCD3Z genetic polymorphism in immune response to hepatitis B vaccination in two independent Chinese populations.
Not available
S-EPMC3329423 | biostudies-literature
ProteomicsGlobal phosphoproteomic analysis of signaling by distinct chimeric antigen receptors reveals kinetic and quantitative differences that influence cell function
Chimeric antigen receptors (CARs) are synthetic proteins that redirect T cell specificity by linking an extracellular ligand binding domain to intracellular T cell signaling domains. CAR-expressing T (CAR-T) cells have demonstrated significant efficacy for the treatment of refractory B cell malignan...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD007921 | Pride
Imac enrichment T cell Chimeric antigen receptor Phosphoprotein signaling Primary t cell Basic reverse phase fractionation Phosphoproteomics Lc-ms/ms 
TranscriptomicsGene expression profile of CAR T cells compared to control ΔCAR T cells
The objective of this experiment was to compare the transcriptional profile of CAR (CD3z endodomain) vs control ΔCAR (truncated version that lacks an endodomain) modified T cells. RNA samples were isolated from trangenic T cells generated from three independent donors.
ORGANISM(S): Homo sapiens 
2018-04-20 | GSE113387 | GEO
TranscriptomicsGene expression profile of SmarT-cells compared to control 1G CAR T cells
The objective of this experiment was to compare the transcriptional profile of T cells modified to express CAR, TBBR and 4/7 ICR (i.e. SmarT-cells) against control 1G CAR T cells expressing CD3z endodomain. RNA samples were isolated from trangenic T cells generated from three independent donors.
ORGANISM(S): Homo sapiens 
2018-04-20 | GSE113391 | GEO
GenomicsCREM is a regulatory checkpoint of CAR and IL-15 signaling in NK cells
This is a preclinical study investigating the role of CREM transcription factor in CAR NK cells. We found thata CREM is a regulatory checkpoint induced by CAR CD3z signaling and IL-15 stimulation that leads to suppression of NK cell function. CREM KO enhances the anti-tumor efficacy of CAR NK cells.
ORGANISM(S): Homo sapiens 
2025-03-14 | GSE267523 | GEO
UnknownImmune response gene expression in colorectal cancer carries distinct prognostic implications according to tissue, stage and site: a prospective retrospective translational study in the context of a hellenic cooperative oncology group randomised trial.
Not available
S-EPMC4430485 | biostudies-literature
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