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TranscriptomicsExpression data from Human CD40L+ Tcells
To assess the nature of CD8+CD40L+ memory Tcells, we compared the gene expression to CD8+CD40L- and CD4+ counterparts, and found similarities in expression of genes encoding cytokines PBMCs were isolated from five healthy donors. The cells were stimulated with PMA/Ionomycin for 6 h, and subsequently...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-44126 | biostudies-arrayexpress
TranscriptomicsGene signature of CLL cells cultured with activated T cells or CD40L-expressing cells
Chronic Lymphocytic Leukemia (CLL) cells multiply in secondary lymphoid tissue but the mechanisms leading to their proliferation are still uncertain. In addition to BCR-triggered signals, other microenvironmental factors might well be involved. In proliferation centres, leukemic B cells are in close...
ORGANISM(S): Homo sapiens 
2013-10-07 | E-GEOD-50572 | biostudies-arrayexpress
TranscriptomicsExpression data from Human CD40L+ Tcells
To assess the nature of CD8+CD40L+ memory Tcells, we compared the gene expression to CD8+CD40L- and CD4+ counterparts, and found similarities in expression of genes encoding cytokines. PBMCs were isolated from five healthy donors. The cells were stimulated with PMA/Ionomycin for 6 h, and subsequentl...
ORGANISM(S): Homo sapiens 
2019-01-30 | E-MTAB-1497 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human islet cells CD40L vs islet cells controls
Expression of CD40 in non-hematopoietic cells has been linked to inflammation. We presented evidence that CD40, a T-cell costimulatory molecule, is expressed in human β-cells and the engagement of CD40 in insulinoma cells activated the NFKB and ERK1/2 pathways. CD40 activation in human islets cell...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-8873 | biostudies-arrayexpress
GenomicsThe T cell-DC CD40L-CD40 axis, but not platelet CD40L, drives atherosclerosis
The T cell-DC CD40L-CD40 axis, but not platelet CD40L, drives atherosclerosis
PRJNA607676 | ENA
TranscriptomicsRNA-seq analysis of neutrophils from CD40L-deficient patients and healthy controls, as well as HL-60 promielocytic cell line
We aim to characterize to effects of the absence of CD40L on neutrophil transcriptome and the effect of soluble CD40L on HL60 cells. For this purpose Total RNA of isolated neutrophils from three CD40L-deficient patients and three healthy controls as well as HL-60 cells from ATCC (HL-60 (ATCC CCL-240...
ORGANISM(S): Homo sapiens 
2017-03-14 | E-MTAB-5316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC T-cell (CD40L+) induced, anti-CD40-siRNA treated
The CD40-CD40L dyad seems to play a prominent role fostering the immune-inflammatory response triggered by endothelial cell (EC)-T cell interaction. To comprehensively delineate the involvement of CD40 (TNFRSF5) in EC activation, we combined RNAi-mediated CD40 knock-down with comparative genome-wide...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-10601 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine Bone marrow derived Dendritic cells stimulated with CD40L in absence or presence of Neural Precursor cell- conditioned medium
We measured global mRNA expression in unstimulated and Bone Marrow Derived Murine Dendritic Cells (BMDCs) stimulated with CD40L in presence or absence of Neuronal precursor cell (NPC) condition medium at 6h and 18h.
ORGANISM(S): Mus musculus 
2017-10-25 | E-MTAB-5307 | biostudies-arrayexpress
GenomicsPrimary Human B-cell Temporal Response to CD40L Stimulation
Primary Human B-cell Temporal Response to CD40L Stimulation
PRJNA549251 | ENA
TranscriptomicsThe T cell-DC CD40L-CD40 axis, but not platelet CD40L, drives atherosclerosis
Atherosclerosis, the underlying vascular cause of cardiovascular disease, has a strong inflammatory component. The co-stimulatory CD40-CD40 ligand (CD40L) signaling axis is a pivotal regulator of immune responses in atherosclerosis. However, therapeutic long-term inhibition of CD40L will severely co...
ORGANISM(S): Mus musculus 
2021-03-16 | GSE145585 | GEO
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