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MetabolomicsCDK4-driven ketogenesis rewires histone modification to promote leukemia

How ketogenic metabolites affect tumorigenesis, and whether ketone metabolism becomes deregulated in cancer cells, remain incompletely understood. Using T-cell acute lymphoblastic leukemia (T-ALL) as a model, we demonstrate that the ketone body β-hydroxybutyrate (BHB) is elevated in cancer cells ...

2026-01-28 | MTBLS13793 | MetaboLights
MetabolomicsFbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells
Not available
ORGANISM(S): Mus musculus 
ST001986 | MetabolomicsWorkbench
MetabolomicsRBC Balanced Immuno-inflammatory Signatures Identify Advanced Breast Cancer Patients on CDK4/6 Inhibitors at Increased Risk of Progression and Death

Recent studies show red blood cell (RBC) plays an essential role in regulating immunity. Nevertheless, the association of immuno-inflammatory parameters, especially RBC balanced signatures, with survival outcomes and adverse events still require investigation for advanced breast cancer (ABC) pati...

2025-04-15 | MTBLS10792 | MetaboLights
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
TranscriptomicsTranscriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study
Microarray analysis of transcriptional changes in biopsies of solid tumors from patients treated in a Phase I study with the Cdk inhibitor PHA-793887. 7 patient biopsies pre- and post-treatment in dye swap. Tumors are of different origins, and are described in the accompanying manuscript.
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-18553 | biostudies-arrayexpress
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle1757
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054832 | Pride
Phosphoproteomics Cdk inhibition Tmt Cdk Cell cycle 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 3344
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054870 | Pride
Phosphoproteomics Cdk inhibition Tmt Cdk Cell cycle 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 2522
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054974 | Pride
Phosphoproteomics Tmt Cdk Cell cycle 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 3174
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD055238 | Pride
Phosphoproteomics Tmt Cdk Cell cycle 
TranscriptomicsRNA-seq of Caenorhabditis elegans at Late L4 stage of WT, daf-2(e1370), daf-16(mgDf50);daf-2(e1370) on control RNAi and cdk-12 RNAi
To check cdk-12 and DAF-16 dependent gene expression change in different genetic backgrounds. We have collected the synchronized late L4 worms and isolated the total RNA and did the mRNA sequencing.
ORGANISM(S): Caenorhabditis elegans 
2023-08-25 | E-MTAB-11189 | biostudies-arrayexpress
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