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GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
ProteomicsCDK12 regulates protein translation independent of kinase activity and its degradation sensitizes colorectal cancer to mTOR inhibition
Despite advances in treatment, colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide, with limited therapeutic options for patients at advanced or metastatic stage. Synthetic lethality represents an emerging strategy that can expand options for patients unresponsive to ex...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD071473 | Pride
Human Colorectal cancer Interaction Cdk12 
ProteomicsCDK12 interaction and knockdown global proteomics
Determining interaction partners with CDK12 using IP-MS. Capturing global proteome expression changes as a result of CDK12 knockdown.
ORGANISM(S): Homo sapiens (Human) 
2017-03-21 | PXD004184 | Pride
Ip-ms Cdk12 Shotgun proteomics 
TranscriptomicsRNA-Seq of Drosophila melanogaster Cdk12-null mutants versus control
In a forward genetic screen, we have previously identified a null mutant of Cdk12 that results in alterations in actin dynamics, the axon initial segment and electrophysiology in Drosophila melanogaster. To decipher how Cdk12 may be having these effects, we extracted RNA from pooled Drosophila heads...
ORGANISM(S): Drosophila melanogaster 
2023-01-01 | E-MTAB-12090 | biostudies-arrayexpress
ProteomicsDiscovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K
The CDK12 inhibitor, SR-4835, promotes the proteasomal degradation of cyclin K, contingent on the presence of CDK12 and the CUL4-RBX1-DDB1 E3 ligase complex. The inhibitor displays molecular glue activity, which correlates with its enhanced ability to inhibit cell growth. This effect is achieved by...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053505 | Pride
Cdk12 Molecular glue degraders Cyclin k 
ProteomicsCDK12 and Integrator-PP2A complex Modulates LEO1 Phosphorylation for Processive Transcription Elongation
Cyclin-dependent kinase 12 (CDK12) interacts with Cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD). To gain a broader understanding of CDK12 cellular function, we used chem...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD038558 | Pride
Cdk12 Transcription elongation Analog-sensitive kinase Rna polymerase ii Leo1 Paf1 complex Intac complex 
GenomicsDual Modes of Gene Regulation by CDK12
Dual Modes of Gene Regulation by CDK12
PRJNA1288348 | ENA
ProteomicsCDK13 cooperates with CDK12 to control global RNA polymerase II processivity
The RNA polymerase II (POLII) driven transcription cycle is tightly regulated at distinct checkpoints through cyclin dependent kinases (CDKs) and their cognate Cyclins. The molecular events underpinning transcriptional elongation and processivity and CDK-Cyclins involved remain poorly understood. Us...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD015453 | Pride
Cdk13 Cdk12 Phosphoproteomics Polymerase 
GenomicsCDK12 maintains phosphorylation of RNA Polymerase II during epidermal differentiation
CDK12 maintains phosphorylation of RNA Polymerase II during epidermal differentiation
PRJNA700840 | ENA
GenomicsCDK12 Regulates DNA Repair Genes by Suppressing Intronic Polyadenylation
CDK12 Regulates DNA Repair Genes by Suppressing Intronic Polyadenylation
PRJNA476800 | ENA
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