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GenomicsDHODH modulates immune evasion of cancer cells via CDP-Choline dependent phospholipid metabolism
DHODH modulates immune evasion of cancer cells via CDP-Choline dependent phospholipid metabolism
PRJNA1018578 | ENA
MetabolomicsCroquemort elicits activation of the immune deficiency pathway in ticks
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...
2023-04-27 | MTBLS686 | MetaboLights
TranscriptomicsDHODH modulates immune evasion of cancer cells via CDP-Choline dependent phospholipid metabolism
The ability of cancer cells to evade immune destruction is governed by various intrinsic factors including their metabolic state. Here we demonstrate that inactivation of dihydroorotate dehydrogenase (DHODH), a pyrimidine synthesis enzyme, increases cancer cell sensitivity to T cell cytotoxicity thr...
ORGANISM(S): Mus musculus 
2025-03-12 | GSE243486 | GEO
UnknownDHODH modulates immune evasion of cancer cells via CDP-Choline dependent regulation of phospholipid metabolism and ferroptosis.
Not available
S-EPMC12022163 | biostudies-literature
ModelsSen2013 - Phospholipid Synthesis in P.knowlesi
Sen2013 - Phospholipid Synthesis in P.knowlesi The model describes the multiple phospholipid synthetic pathways in Plasmodium knowlesi. This model is described in the article: Kinetic modelling of phospholipid synthesis in ...
2024-09-02 | BIOMD0000000495 | BioModels
MetabolomicsGenetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 2)
Not available
ORGANISM(S): Plasmodium falciparum 
ST002107 | MetabolomicsWorkbench
MetabolomicsGenetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 1)
Not available
ORGANISM(S): Plasmodium falciparum 
ST002106 | MetabolomicsWorkbench
MetabolomicsGenetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 3)
Not available
ORGANISM(S): Plasmodium falciparum 
ST002108 | MetabolomicsWorkbench
Unknown1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway.
Not available
S-EPMC5682592 | biostudies-literature
UnknownEvidence for Peroxisomal Dysfunction and Dysregulation of the CDP-Choline Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Not available
S-EPMC8764736 | biostudies-literature
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