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During S-phase of the eukaryotic cell cycle, controls exist to ensure that replication origins fire only once and become inactivated after traverse of a replication fork. Failure of these controls results in local amplification of the genome which can lead to gene copy increases important for both ...
ORGANISM(S): Schizosaccharomyces pombe 
au13-04_cdtbis; cdt1_bis crl mutants and CDT1-RNAi lines have very similar macroscopic phenotypes as well as identical defects in plastid division and biogenesis. Our goal wwas to determine how much of these similarities originated from similar alterations of gene expression. Plantlets of crl mutan...
ORGANISM(S): Arabidopsis thaliana 
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage
To examine origin firing upon CDT1 overexpression, EdUseq-HU was performed in HCT116 cells with normal expression levels of CDT1 (OFF) and HCT116 cells with CDT1 overexpression (ON)
ORGANISM(S): Homo sapiens 
2023-09-01 | GSE212710 | GEO
rs04-06_cdt1 - cdt1 - CDT1 is a protein of the pre-replication complex, and accumulates during the G1-S transition, thus play a major role in S-phase entry - Comparison of 3 independant RNAi lines Keywords: normal vs rnai mutant comparaison
ORGANISM(S): Arabidopsis thaliana 
2007-08-09 | GSE8698 | GEO
rs04-06_cdt1 - cdt1 - CDT1 is a protein of the pre-replication complex, and accumulates during the G1-S transition, thus play a major role in S-phase entry - Comparison of 3 independant RNAi lines Keywords: normal vs rnai mutant comparaison
ORGANISM(S): Arabidopsis thaliana 
2007-06-20 | GSE7997 | GEO
au13-04_cdtbis; cdt1_bis crl mutants and CDT1-RNAi lines have very similar macroscopic phenotypes as well as identical defects in plastid division and biogenesis. Our goal wwas to determine how much of these similarities originated from similar alterations of gene expression. Plantlets of crl mutant...
ORGANISM(S): Arabidopsis thaliana 
2013-09-01 | GSE48465 | GEO
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