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TranscriptomicsExpression data from transfected IB3 cells transfected with CFTR mutants
CFTR plasmid constructs were transfected in CF Bronchial IB3 cell cultures using Lipofectamine 2000™. Global gene mRNA expression profiles at 48 hr after transfection were created with the Affymetrix U133 chip set. We used microarrays to detail the global changes in gene expression occuring as a re...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-28072 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cystic fibrosis (CF) IB3-1 bronchial epithelial cells treated with 4-phenylbutyrate for 12 or 24 hours to study the drug's influence on heat-shock proteins in CF
Most individuals with cystic fibrosis (CF) carry one or two mutations that result in a maturation defect of the full-length CFTR protein. The deltaF508 mutation results in a mutant protein that is degraded by the proteasome instead of progressing to the apical membrane where it functions as a cycli...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-620 | biostudies-arrayexpress
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