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TranscriptomicsZFP-1(AF10)/DOT-1 Complex Opposes H2B Ubiquitination to Reduce Pol II Transcription
Inhibition of transcriptional elongation plays an important role in gene regulation in metazoans, including C. elegans, which lacks Negative Elongation Factor homologs. Here we combine genomic and biochemical approaches to dissect a novel role of C. elegans AF10 homolog, ZFP-1, in transcriptional c...
ORGANISM(S): Caenorhabditis elegans 
2013-07-05 | E-GEOD-47132 | biostudies-arrayexpress
TranscriptomicsGlobal effects of the CSR-1 RNA interference pathway on transcriptional landscape
Argonaute proteins and their small RNA co-factors short interfering RNAs (siRNAs) are known to inhibit gene expression at the transcriptional and post-transcriptional levels. In Caenorhabditis elegans, the Argonaute CSR-1 binds thousands of endogenous siRNAs (endo-siRNAs) antisense to germline trans...
ORGANISM(S): Caenorhabditis elegans 
2014-02-28 | E-GEOD-49946 | biostudies-arrayexpress
TranscriptomicsPromoters Recognized by Forkhead Proteins Exist for Individual 21U-RNAs
C. Elegans 21U-RNAs are equivalent to the piRNAs discovered in other metazoans and have important roles in gametogenesis and transposon control. The biogenesis and molecular function of 21U-RNAs and piRNAs are poorly understood. Here, we demonstrate that transcription of each 21U-RNA is regulated se...
ORGANISM(S): Caenorhabditis elegans 
2012-05-28 | E-GEOD-38253 | biostudies-arrayexpress
UnknownSignificance of PD-L1 in Metastatic Urothelial Carcinoma Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.
Not available
S-EPMC10918499 | biostudies-literature
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