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TranscriptomicsGenomic Loss of Penicillin-Binding Protein 3 in Burkholderia pseudomallei Confers Clinical Resistance to Ceftazidime
Array-CGH analysis and Burkholderia pseudomallei isolates pre and post ceftazidime relapse. Genomic DNA from both the parental strains and variant strains were labeled with Cy3 or Cy5 fluorescent dyes and hybridized onto a customized microarray with probes designed from the reference Bp K96243 genom...
ORGANISM(S): Burkholderia pseudomallei 
2011-10-06 | E-GEOD-25832 | biostudies-arrayexpress
MetabolomicsGlutamate-mediated metabolic rewiring boosts CpxA/R-OmpF porin and proton motive force to resensitize antibiotic-resistant Escherichia coli to ceftazidime

Ceftazidime (CAZ) is a critically important broad-spectrum antibiotic widely used in clinical practice. However, the rapid emergence of bacterial resistance to CAZ poses a significant challenge in treating infections caused by multidrug-resistant pathogens. In this study, we employed a metabolism...

2026-01-20 | MTBLS13732 | MetaboLights
TranscriptomicsExpression data from PAO1 and its creBC derivative mutant (PAOM-NM-^TcreBC)
We used microarrays to determine the expression profile of the P. aeruginosa creBC mutant regarding its parental wild type strain PAO1. Expression analysis from three independent replicates of PAO1 and its creBC derivative mutant (PAOM-NM-^TcreBC) were performed under basal conditions and with cef...
ORGANISM(S): Pseudomonas aeruginosa 
2014-06-25 | E-GEOD-58758 | biostudies-arrayexpress
TranscriptomicsTranscriptomics analysis during the transient ceftazidime tolerance of Burkholderia pseudomallei
B. pseudomallei strain K96243 is sensitive to the drug ceftazidime (CAZ), but has been shown to exhibit transient CAZ tolerance when in a biofilm form. To investigate an observed shift in gene expression profile during ceftazidime (CAZ) tolerance and to better understand the mechanistic aspects of t...
ORGANISM(S): Burkholderia pseudomallei K96243 
2021-06-30 | GSE168275 | GEO
TranscriptomicsPseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC.
We compared the dynamics and mechanisms of resistance development to ceftazidime, meropenem, ciprofloxacin, and ceftolozane-tazobactam in wild-type (PAO1) and mutator (PAOMS, M-bM-^HM-^FmutS) P. aeruginosa. The strains were incubated for 24 h with 0.5 to 64M-CM-^W MICs of each antibiotic in triplica...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2014-06-12 | E-GEOD-58390 | biostudies-arrayexpress
GenomicsGenomic Loss of Penicillin-Binding Protein 3 in Burkholderia pseudomallei Confers Clinical Resistance to Ceftazidime
Array-CGH analysis and Burkholderia pseudomallei isolates pre and post ceftazidime relapse.
ORGANISM(S): Burkholderia pseudomallei Burkholderia pseudomallei K96243 
2011-10-07 | GSE25832 | GEO
GenomicsTranscriptomics analysis during the transient ceftazidime tolerance of Burkholderia pseudomallei
Transcriptomics analysis during the transient ceftazidime tolerance of Burkholderia pseudomallei
PRJNA706721 | ENA
GenomicsWhole-Genome Sequencing of Ceftazidime-Avibactam resistant KPC-producing Klebsiella pneumoniae strains
Emergence of Ceftazidime-Avibactam resistant KPC-producing K. pneumoniae (KPC-Kp) during ceftazidime-avibactam-based antimicrobial treatment.
PRJEB21871 | ENA
GenomicsSusceptibility to ceftazidime/avibactam in German MDR/XDR Pseudomonas aeruginosa
Susceptibility to ceftazidime/avibactam in German MDR/XDR Pseudomonas aeruginosa
PRJEB30639 | ENA
TranscriptomicsTranscription profiling of human cell line THP-1 cells exposed to Daboiatoxin and cytokines involved in melioidosis caused by B. pseudomalli
Gene expression profiles of human cell (THP-1) lines exposed to a novel Daboiatoxin (DbTx) isolated from Daboia russelli russelli, and specific cytokines and inflammatory pathways involved in acute infection caused by Burkholderia pseudomallei. Experiment Overall Design: 1. Group I:- Human monocytic...
ORGANISM(S): Homo sapiens 
2009-04-04 | E-GEOD-7577 | biostudies-arrayexpress
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