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TranscriptomicsDifferent isoforms of Maxwell´s Demon, a conserved cell membrane protein, mediate lose/win decisions during cell competition
Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays we have identified Maxwell`s Demon (Mwd), a cell membr...
ORGANISM(S): Drosophila melanogaster 
2011-02-09 | E-GEOD-21230 | biostudies-arrayexpress
MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
TranscriptomicsCell competition regulates thymocyte turnover
Wild type thymi were transplanted into a competitive (wild type hosts), or non-competitive (Rag2-/-γc-/-KitW/Wv hosts) environment. Triple negative 2 and 3 (TN2/3) stages were sorted 14 days afetr transplantation and separated for cells of host or donor origin. Global gene expression data for TN2/3 ...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56418 | biostudies-arrayexpress
TranscriptomicsCell competition is a tumor suppressor mechanism in the thymus.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56419 | biostudies-arrayexpress
TranscriptomicsMyc mild overexpression in the heart in a mosaic fashion induces matabolic changes and triggers hipertrophic protection pathways without a pathological phenotype
Recently, it was described that mammalian cells are able to eliminate those with relative lower Myc levels in the epiblast through cell competition. We have described that cardiomyocytes during heart development are also able to complete eliminating cells with lower Myc levels. We have also shown th...
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-58858 | biostudies-arrayexpress
TranscriptomicsTranscriptome analyses during disease progression
Transcriptome was assessed in the transitions from the normal thymus (with regular progenitor turnover), to a thymus devoid of extrinsic progenitor competition for 10 weeks, to fully malignant T cell acute lymphoblastic leukemia (T-ALL). Comparison of global gene expression between normal thymus, to...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56417 | biostudies-arrayexpress
TranscriptomicsUNIL-intraspecific competition
Root and leaf transcriptomes of Arabidopsis plants growing alone or subjected to intraspecific competition
ORGANISM(S): Arabidopsis thaliana 
2012-12-06 | E-MEXP-3735 | biostudies-arrayexpress
ProteomicsPhosphotyrosine proteomics of MDCK cell
MDCK cell with Src-overexpression (wild type or mutant) were trypsinized, and enriched with Fe-IMAC. After labelling with TMT 10plex reagent, phosphotyrosine peptides were further enriched with phosphotyrosine antibodies. The enriched peptides were analyzed with Q Exactive Plus.
ORGANISM(S): Homo Sapiens (human) 
2023-03-31 | PXD032878 | JPOST Repository
TranscriptomicsIntrathymic origins of T-ALL
Leukemia cells are considered developmentally 'frozen', and their phenotype is thought to reflect their stage of origin. To gain insights into the cell population from which T-ALL arises, we compared by global gene expression profiling T-ALL samples (n = 10) to different stages of T cell development...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56416 | biostudies-arrayexpress
GenomicsCompetition but not cross-competition controls T cell proliferation in transplant patients following cytomegalovirus reactivation
Competition but not cross-competition controls T cell proliferation in transplant patients following cytomegalovirus reactivation
PRJNA705213 | ENA
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