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GenomicsDistinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells [ChIP-seq & ATAC-seq]
Innate lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory mediators, rapidly communicating danger via cytokine secretion, and functioning as guardians of tissue homeostasis. Although ILCs have been studied extensively in model organisms, little is kn...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-77299 | biostudies-arrayexpress
TranscriptomicsDistinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells [gene expression]
Innate lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory mediators, rapidly communicating danger via cytokine secretion, and functioning as guardians of tissue homeostasis. Although ILCs have been studied extensively in model organisms, little is kn...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-78896 | biostudies-arrayexpress
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
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