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MetabolomicsNano-formulated bisphosphonate adjuvants simultaneously induce humoral and cellular immunity
Adjuvant is an important component of vaccines However, given the limitation of existing adjuvants in variety and mechanism, developing a unique and effective adjuvant is urgently needed for clinal applications. Recent studies have implicated that the mevalonate pathway plays an essential role in va...
2026-03-03 | MTBLS11696 | MetaboLights
MetabolomicsFunctional specialization of bacterial cellular and extracellular fractions contributes to polysaccharide degradation

Bacteroides thetaiotaomicron (Bt), a key commensal of the human gut microbiota, exhibits robust capacity to degrade dietary polysaccharides via carbohydrate-active enzymes (CAZymes). However, the exact spatial distribution and the functional coordination of these enzymes remain poor...

2026-03-27 | MTBLS14156 | MetaboLights
MetabolomicsInteraction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways a...

2025-07-22 | MTBLS12761 | MetaboLights
MetabolomicsA neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights
MetabolomicsThe Lipopolysaccharide-Induced Metabolome Signature in Arabidopsis thaliana Reveals Dynamic Reprogramming of Phytoalexin and Phytoanticipin Pathways
Lipopolysaccharides (LPSs), as MAMP molecules, trigger the activation of signal transduction pathways involved in defence. Currently, plant metabolomics is providing new dimensions into understanding the intracellular adaptive responses to external stimuli. The effect of LPS on the metabolomes of Ar...
2017-05-03 | MTBLS272 | MetaboLights
MetabolomicsConserved cellular signals and mechanisms accompany the reproductive shutdown of honey bee (Apis mellifera) queens for dispersal
Temporal reproductive plasticity is a central life-history trait for most iteroparous animals, yet its underlying molecular mechanisms remain poorly understood. We utilize the reversible reproductive arrest experienced by honey bee queens during colony swarming to investigate how these reproductive ...
2026-04-09 | MTBLS14234 | MetaboLights
MetabolomicsExploratory metabolomic profiling in migraine with PFO: dysregulated pathways and potential biomarkers

Background: Emerging evidence implicates patent foramen ovale (PFO) as a potential contributor to migraine through paradoxical metabolite shunting, microembolism and hypoxemia. However, systematic characterization of metabolic alterations in migraine patients with PFO (PFO-M) remains un...

2026-03-26 | MTBLS13630 | MetaboLights
MetabolomicsHepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease, however, recent advances support the notion that sepsis is accompanied by extensive metabolic ...

2020-01-10 | MTBLS1386 | MetaboLights
MetabolomicsComparative metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum reveals fundamental differences in active metabolic pathways and suggests novel gene annotations
Mycoplasmas are simple, but successful parasites that have the smallest genome of any free-living cell and are thought to have a highly streamlined cellular metabolism. Here we have undertaken a detailed metabolomic analysis of two species, Mycoplasma bovis and Mycoplasma gallisepticum, which cause ...
2017-10-10 | MTBLS535 | MetaboLights
MetabolomicsComparative metabolomics and transcriptomics revealed multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
Polymyxins are the last-line antibiotics against multidrug-resistant Pseudomonas aeruginosa however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study e...
2018-11-14 | MTBLS751 | MetaboLights
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