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TranscriptomicsUtilization of redundant dBPs in cells with altered levels of MXE regulators
Usage of intron lariat junctions of human and chicken KGDH transcripts in cells expressing Ca2+-dependent isoforms.
ORGANISM(S): Gallus gallus 
2021-02-07 | E-MTAB-9412 | biostudies-arrayexpress
TranscriptomicsA comprehensive and universal method for assessing the performance of differential gene expression analyses
The number of methods for pre-processing and analysis of gene expression data continues to increase, often making it difficult to select the most appropriate approach. We present a simple procedure for the comparative estimation of a variety of methods for microarray data pre-processing and analysis...
ORGANISM(S): Homo sapiens 
2010-11-09 | E-GEOD-22630 | biostudies-arrayexpress
TranscriptomicsPbx1-d Induces T cell Activation and a Decreased Apoptosis in Response to Retinoic Acids (RA)
The hypothesis was tested that the Pbx1-d isoform was responsible for the Sle1a.1 phenotypes in CD4+ T cells. Jurkat T cells were transfected with a lentiviral construct expressing Pbx1-d-GFP or control RFP. Pbx1-d over-expression reduced the percentage of late apoptotic cells in response to anti-C...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22799 | biostudies-arrayexpress
Transcriptomicsp53 amplifies Toll-like receptor 5 response in MCF-7 cells
Using gene expression profiling we characterize the global effect of p53 on the TLR5-mediated transcription in MCF7 cells. We found that combined activation of p53 and TLR5 pathways synergistically increases expression of over 200 genes, mostly associated with immunity and inflammation. The synergy ...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-72359 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human PBMC response to benzene metabolites
analyzed changes in cytokine/chemokine production and gene expression levels in, human peripheral blood mononuclear cells upon teratment with 15µM,2,4-benzenetriol Experiment Overall Design: Two groups of PBMC samples treated (Bt5) and nontreated (med); each group was biologically replicated 8 time...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-7664 | biostudies-arrayexpress
TranscriptomicsDLD1
DLD1 is an APC mut, KRAS mut, P53 mut CRC cell line. PROX1 transcription factor, target of Wnt pathway in CRC, is our protein of interest.DLD1 cells are PROX1 negative. We overexpressed through lentiviral expression PROX1 protein or the empty vector psd44, through selection of the cells in puromycin...
ORGANISM(S): Homo Sapiens 
2014-09-18 | E-MTAB-2020 | biostudies-arrayexpress
TranscriptomicsSW480R
SW480R is an APC mut, KRAS mut, P53 mut CRC cell line. PROX1 transcription factor, target of Wnt pathway in CRC, is our protein of interest.SW480R cells are PROX1 positive. We suppressed through siRNA transfection the expression of PROX1 protein or non-targeting siRNA, using two different siRNA. Aft...
ORGANISM(S): Homo Sapiens 
2014-09-18 | E-MTAB-2021 | biostudies-arrayexpress
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