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MetabolomicsSensing Ceramides by CYSLTR2 and P2RY6 to Aggravate Atherosclerosis

Recent evidence shows elevated circulating long-chain ceramide levels predicts atherosclerotic cardiovascular disease (ASCVD) independently of cholesterol. Although targeting ceramides signaling may provide therapeutic benefits beyond the treatment of hypercholesterolemia, the underlying mechanis...

2025-04-15 | MTBLS11925 | MetaboLights
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
MetabolomicsTargeting Myelin Ceramides in PAR1 and PAR2 Mice after SCI
Not available
ORGANISM(S): Mus musculus 
ST000864 | MetabolomicsWorkbench
MetabolomicsQuantitative measurements of ceramides and glycosphingolipids in Th17 and iTreg cells (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001675 | MetabolomicsWorkbench
MetabolomicsEffects of Curcumin Supplementation on the Ceramides Concentration of Older Adults: Relation to Vascular Function (part 3)
Not available
ORGANISM(S): Homo sapiens 
ST000526 | MetabolomicsWorkbench
MetabolomicsTrace 13C-glucose, 13C-glutamine, and 13C-serine in genetically engineered pancreatic cell lines through ceramides (part III)
Not available
ORGANISM(S): Homo sapiens 
ST000644 | MetabolomicsWorkbench
GenomicsCeramides Drive Mitochondrial Dysfunction and Tubular Injury in AKI
Ceramides Drive Mitochondrial Dysfunction and Tubular Injury in AKI
PRJNA1199041 | ENA
TranscriptomicsUnsaturation of very-long-chain ceramides regulates hypoxia response by modulating ethylene signaling in Arabidopsis
Lipid remodeling is crucial for hypoxic tolerance in animals, whilst little is known about the hypoxia-induced lipid dynamics in plant cells. Here we performed a mass spectrometry-based analysis to survey the lipid profiles of Arabidopsis rosettes under various hypoxic conditions. We observed that h...
ORGANISM(S): Arabidopsis thaliana 
2016-07-24 | E-GEOD-59719 | biostudies-arrayexpress
GenomicsRemoving a Double Bond from Ceramides Ameliorates Insulin Resistance and Hepatic Steatosis
Removing a Double Bond from Ceramides Ameliorates Insulin Resistance and Hepatic Steatosis
PRJNA545734 | ENA
TranscriptomicsCeramides Drive Mitochondrial Dysfunction and Tubular Injury in AKI
Perturbations in proximal tubule mitochondrial function and lipid metabolism potentiate kidney dysfunction in acute kidney injury (AKI). We identified the bioactive lipid ceramides as drivers of proximal tubule pathology in AKI. Ceramide synthesis was upregulated in humans and mice with AKI. We util...
ORGANISM(S): Mus musculus 
2025-12-17 | GSE284451 | GEO
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