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TranscriptomicsChemosensitization of DLBCL cells in vitro and in vivo by demethylating nucleoside analogues [gene expression]
Silencing of genes that suppress the malignant phenotype by DNA methylation spurred an interest in the clinical use of epigenetic reprogramming agents. Single therapy is unlikely to be curative in the context of a heterogeneous disease such as Diffuse Large B cell Lymphomas (DLBCL). The combination ...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-28744 | biostudies-arrayexpress
TranscriptomicsCombinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphoma
Aggressive double and triple hit (DH/TH) DLBCL feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls post-transcriptional dynamics of key mRNA species including those encoding BCL6, MYC and BCL2. Using a proteomics approach, we found that Hsp90 binds to and maintains acti...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-63265 | biostudies-arrayexpress
TranscriptomicsIntegrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
We have found that thyroid hormones (THs), acting as soluble integrin αvβ3 ligands, activate growth-related signaling pathways in T-cell lymphomas (TCL). Specifically, TH-activated αvβ3 integrin signaling promotes TCL proliferation and angiogenesis, in part, via the up-regulation of VEGF. CUTLL1 cel...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-63122 | biostudies-arrayexpress
TranscriptomicsBCL6 repression of EP300 provides a basis for rational combinatorial therapy in diffuse large B cell lymphomas.
The BCL6 transcriptional repressor is a critical oncogene in diffuse large B-cell lymphomas (DLBCL). The specific BCL6 inhibitor RI-BPI potently kills DLBCL cells. We find that RI-BPI induces a particular gene expression signature in DLBCL. In order to identify classes of drugs that might synergize ...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-24236 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsChemosensitization of DLBCL cells in vitro and in vivo by demethylating nucleoside analogues [methylation]
Silencing of genes that suppress the malignant phenotype by DNA methylation spurred an interest in the clinical use of epigenetic reprogramming agents. Single therapy is unlikely to be curative in the context of a heterogeneous disease such as Diffuse Large B cell Lymphomas (DLBCL). The combination ...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-31101 | biostudies-arrayexpress
UnknownThe eukaryotic translation initiation factor eIF4E reprogrammes alternative splicing
Not available
S-SCDT-10_15252-EMBJ_2021110496 | biostudies-other
TranscriptomicsGene expression data of interleukin-7-dependent and BCR-ABL1-transformed pre-B cells
This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including immunoglobulin light chain gene recombination were performed by withdrawal of interleuki...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21664 | biostudies-arrayexpress
TranscriptomicsImatinib Disrupts Lymphoma Angiogenesis by Targeting Vascular Pericytes
Pericytes/vascular smooth muscle cells (VSMCs), regulated by platelet-derived growth factor receptor β (PDGFRβ) signaling, play important roles in endothelial survival and vascular stability. Here we report that treatment with imatinib, an inhibitor of PDGFRβ, led to significant tumor growth impairm...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-30752 | biostudies-arrayexpress
TranscriptomicsComparison of copy number variations between wildtype and BCL6 knockout BCR-ABL1-driven acute lymphoblastic leukemia
This comparative genomic hybridization (CGH) study investigated the effect of BCL6 on clonal evolution in BCR-ABL1-driven acute lymphoblastic leukemia (ALL). The frequencies of copy number alterations in BCR-ABL1-transformed BCL6+/+ and BCL6-/- leukemias were determined. Three BCR-ABL1-transformed B...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-24400 | biostudies-arrayexpress
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