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TranscriptomicsAtaxia-telangiectasia cerebellar cortex expression
Cerebellar cortex expression in ataxia-telangiectasia patients and normal controls. The neurodegenerative disease known as ataxia-telangiectasia (A-T) is caused by the absence of the ATM (A-T mutated) protein. A long-standing mystery surrounding A-T is why cerebellar Purkinje cells (PCs) appear uni...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-61019 | biostudies-arrayexpress
TranscriptomicsGene expression in primate postnatal brain through lifespan - cerebellar cortex
We investigated molecular changes during human, chimpanzee, and rhesus macaque postnatal brain development at the transcriptome, proteome, and metabolome levels in two brain regions: the prefrontal cortex (PFC) that is involved in several human-specific cognitive processes, and the cerebellar cortex...
ORGANISM(S): Macaca mulatta 
2011-12-09 | E-GEOD-22569 | biostudies-arrayexpress
TranscriptomicsA mouse model of the most aggressive subgroup of human medulloblastoma [HT_MG-430_PM]
A series of mouse models designed to mimic pediatric medulloblastoma types in humans were tested by microarray and compared to published human medulloblastoma data Myc-type tumors [dka201-203] were generated by orthotopic injection of Myc-infected cerebellar cells from Cdkn2c-/-, Trp53-/-, Atoh1-GFP...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33200 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prefrontal cortex during postnatal development
Fresh frozen post mortem prefrontal cortex tissue (Brodman area 46) was obtained from 44 individuals varying in age from 0 to 49 years. RNA was extracted from these samples and hybridized to HG133plus2.0 GeneChips. The data was used to examine patterns of gene expression over the course of human pos...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-13564 | biostudies-arrayexpress
TranscriptomicsPC transcriptome
During the first 10 postnatal days of mouse development, Purkinje cells, neurons of the cerebellum, pass through different developmental processes of differentiation such as profound dendritic remodeling and growth, cell death and loss of their ability to regenerate their axons. To identify the gene...
ORGANISM(S): Mus musculus 
2012-03-15 | E-MEXP-3444 | biostudies-arrayexpress
GenomicsBulk-tissue RNA-sequencing paired nuclear and cytoplasmic fractions of anterior prefrontal cortex, cerebellar cortex and putamen tissues from 4 post-mortem neuropathologically-confirmed control individuals ( anterior prefrontal cortex & cerebellar cortex – 4 individuals, putamen- 3 individuals) .
Gaining insight into the genetic regulation of gene expression in human brain is key to the interpretation of genome-wide association studies for major neurological and neuropsychiatric diseases. Expression quantitative trait loci (eQTL) analyses have largely been used to achieve this, providing val...
EGAS00001006380 | EGA
TranscriptomicsmRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar c...
ORGANISM(S): Homo sapiens 
2009-08-29 | E-GEOD-12297 | biostudies-arrayexpress
TranscriptomicsGene expression in primate postnatal brain through lifespan
This SuperSeries is composed of the following subset Series: GSE22521: Gene expression in primate postnatal brain through lifespan - prefrontal cortex GSE22569: Gene expression in primate postnatal brain through lifespan - cerebellar cortex Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-12-09 | E-GEOD-22570 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hippocampal CA1 and CA3, cerebral cortex, and cerebellar granular layer brain regions
Study on selective vulnerability of certain brain regions to oxidative stress. Here we selected 4 brain regions (hippocampal CA1 and CA3, cerebral cortex, and cerebellar granular layer) to study this phenomenon. Experiment Overall Design: Neurons were collected from the 4 regions of the rat brain an...
ORGANISM(S): Rattus norvegicus 
2008-04-07 | E-GEOD-7139 | biostudies-arrayexpress
GenomicsCNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma.
CNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma.
PRJNA1274024 | ENA
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