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MetabolomicsMetabolomic profiling of cerebrospinal fluid from dogs with meningoencephalitis of unknown origin by nuclear magnetic resonance

Introduction: Meningoencephalitis of unknown origin (MUO) in dogs is a very debilitating and potentially fatal disease that is a potential model for multiple sclerosis in humans. The metabolomic profile of MUO has not been previously reported.

Objectives: To describe the metabolomic profile...

2026-03-05 | MTBLS6053 | MetaboLights
MetabolomicsMulti-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approache...
2021-11-04 | MTBLS2689 | MetaboLights
MetabolomicsAlterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington’s disease subjects
Huntington's disease (HD) is a severe neurological disease leading to psychiatric symptoms, motor impairment and cognitive decline. The disease is caused by a CAG expansion in the huntingtin (HTT) gene, but how this translates into the clinical phenotype of HD remains elusive. Using liquid chromatog...
2019-06-21 | MTBLS749 | MetaboLights
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
TranscriptomicsTranscriptional profiling of cerebrospinal fluid cells of multiple sclerosis patients
RNA was isolated from fresh cerebrospinal fluid samples of multiple sclerosis and control patients and analyzed by hybridization of HG U133 plus 2.0 arrays in order to investigate disease mechanisms of multiple sclerosis and to identify transcriptional biomarker
ORGANISM(S): Homo sapiens 
2014-06-01 | E-MTAB-2374 | biostudies-arrayexpress
MetabolomicsBiomarkers for Depression in Human Cerebrospinal Fluid in a Population Sample
Not available
ORGANISM(S): Homo sapiens 
ST000063 | MetabolomicsWorkbench
MetabolomicsComparative analysis of metabolomic profiles in cerebrospinal fluid before and after endurance exercise
Not available
ORGANISM(S): Homo sapiens 
ST001780 | MetabolomicsWorkbench
ProteomicsProteomics of cerebrospinal fluid microvesicles
Comprehensive proteomic dataset of cerebrospinal fluid (CSF) microvesicles. The aim of this study is to deeply characterize the protein content of microvesicles (MVs) isolated from human cerebrospinal fluid. MVs were isolated from Two CSF pools and their proteome was studied with high sensitivity ma...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080277 | MassIVE
ProteomicsPhosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscal...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD040744 | JPOST Repository
MetabolomicsImpact of nitisinone on the cerebrospinal fluid metabolome of a murine model of alkaptonuria
Not available
ORGANISM(S): Mus musculus 
ST002179 | MetabolomicsWorkbench
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