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GenomicsTargeting CERT sensitizes AML Cells to FLT3 Inhibitors through activating GRP78-ATF6-CHOP Axis
Targeting CERT sensitizes AML Cells to FLT3 Inhibitors through activating GRP78-ATF6-CHOP Axis
PRJNA1178294 | ENA
TranscriptomicsTargeting CERT sensitizes AML Cells to FLT3 Inhibitors through activating GRP78-ATF6-CHOP Axis
Ceramide Transfer Protein (CERT) determines the ratio of ceramide and Sphingomyelin in cells. Targeting CERT sensitizes solid cancer cells to chemotherapy. However, the role of CERT in AML remains elusive. Knockdown CERT or its inhibitor HPA-12 inhibited growth and promoted apoptosis in AML cells ca...
ORGANISM(S): Homo sapiens 
2024-12-01 | GSE280391 | GEO
GenomicsVAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
RNA transfer via extracellular vesicles (EVs) influences cell phenotypes; however, lack of information regarding biogenesis of RNA-containing EVs has limited progress in the field. Here, we identify endoplasmic reticulum membrane contact sites (ER MCS) as platforms for generation of RNA-containing E...
ORGANISM(S): Homo sapiens 
2022-04-05 | GSE188223 | GEO
GenomicsVAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
PRJNA777941 | ENA
UnknownRationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation.
Not available
S-EPMC6351896 | biostudies-literature
UnknownHyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum.
Not available
S-EPMC8999913 | biostudies-literature
UnknownLiposomal FRET Assay Identifies Potent Drug-Like Inhibitors of the Ceramide Transport Protein (CERT).
Not available
S-EPMC7756341 | biostudies-literature
UnknownHerpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the interorganelle transport protein CERT.
Not available
S-EPMC9668737 | biostudies-literature
UnknownIntellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT.
Not available
S-EPMC7751862 | biostudies-literature
UnknownInvolvement of a Cluster of Basic Amino Acids in Phosphorylation-Dependent Functional Repression of the Ceramide Transport Protein CERT.
Not available
S-EPMC9368931 | biostudies-literature
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