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MetabolomicsInsight into the complex interaction between vaginal microbiome, metabolome, and host gene expression in cervical cancer progression

This study aimed to highlight the relationships between vaginal microbiome composition, metabolic alterations, and gene expression changes during cervical cancer. Multi-omics analysis for the healthy (Z group), abortion (AB group), HPV infection (HP group), and cervical cancer group (CC group), q...

2025-11-26 | MTBLS10477 | MetaboLights
MetabolomicsMetabolomics and Proteomics Reveal the Inhibitory Effect of Lactobacillus crispatus on Cervical Cancer Cells
Cervical cancer remains a significant global health issue due to its high morbidity and mortality rates. Recently, Lactobacillus crispatus has been recognized for its crucial role in maintaining cervical health. While some studies have explored the use of L. crispatus to mitigate cervical cancer, th...
2024-09-05 | MTBLS10498 | MetaboLights
MetabolomicsLaser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening

BACKGROUND: The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but ha...

2022-02-15 | MTBLS1371 | MetaboLights
MetabolomicsDistinct Cervical Microbiome and Metabolite Profiles Before and After Menopause: Implications for Cervical Cancer Progression

Introduction: Cervical cancer is the fourth most common malignancy in women and is primarily caused by persistent infection with high-risk human papillomavirus (HPV). In addition, host immune responses, genetic factors, and lifestyle habits also have etiological roles. The cervicovaginal microbio...

2025-07-07 | MTBLS12691 | MetaboLights
ProteomicsBiomarkers for Cervical Cancer. iTRAQ Discovery.
We developed a discovery-validation mass-spectrometry based pipeline to identify a set of proteins that are regulated in serum of patients with cervical intraepithelial neoplasia (CIN) and squamous cell cervical cancer using isobaric Tags for Relative and Absolute Quantitation (iTRAQ®), label-free ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079925 | MassIVE
ProteomicsPlasma extracellular vesicle miRNA profiling in cervical cancer patients and healthy controls
Cervical cancer (CC) is a malignancy characterized by persistent HPV infection and tumor microenvironment remodeling. To explore the molecular characteristics of plasma extracellular vesicles (EVs) in CC, we performed miRNA sequencing on plasma EVs from 3 CC patients and 3 healthy controls. Differen...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071100 | Pride
Cervical cancer Blood 
ProteomicsEnhancing Concurrent Chemoradiation Outcome Prediction for Locally Advanced Cervical Cancer Patients Through Plasma Extracellular Vesicle Proteomics Analysis
Majority of the patients with cervical cancer present with locally advanced cervical cancer (LACC), which is primarily treated using concurrent chemoradiation (CCRT) and lacks reliable predictive biomarkers. Extracellular vesicles (EVs) could potentially define the dynamic biological response to CCR...
ORGANISM(S): Homo Sapiens (human) 
PXD050754 | JPOST Repository
ProteomicsQuantitative proteomic study of two cervical cancer cell lines upon re-expression of Galectin 7
Galectin-7 expression was found to be strongly reduced in cervical cancer cell lines. The same tumor cell lines in which Galectin-7 was ectopically expressed exhibited significant decrease in their tumorigenic capacity in vitro and in vivo. The proteomic changes in the cervical cancer cell lines HeL...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080855 | MassIVE
TranscriptomicsFunctional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles
Although gain of chromosome-5p is one of the most frequent DNA copy number imbalances in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly understood. In a previous cross-sectional clinical study we showed that the microRNA processor Drosha (located on chromoso...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-26177 | biostudies-arrayexpress
GenomicsWhole exome sequencing of Cervical Squamous samples
The raw data consist of whole exome sequencing data of cervical squamous samples
ORGANISM(S): Homo sapiens 
2022-02-11 | E-MTAB-11407 | biostudies-arrayexpress
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