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TranscriptomicsGenome-wide gene expression analysis in Thoc5- and CFIm68-depleted HeLa cells
We found that CFIm68, a mRNA cleavage and polyadenylation factor implicated for alternative polyadenylation site choice, was co-purified with Thoc5, a component of human THO/TREX. Microarray analysis using human HeLa cells reveals knockdown of Thoc5 affects the expression of a subset of non-heat sho...
ORGANISM(S): Homo sapiens 
2013-05-21 | E-GEOD-42327 | biostudies-arrayexpress
UnknownEffect of CFIm68 knockdown on RNA polymerase II transcription.
Not available
S-EPMC6720987 | biostudies-literature
TranscriptomicsGenome-wide gene expression analysis in Thoc5- and CFIm68-depleted HeLa cells
We found that CFIm68, a mRNA cleavage and polyadenylation factor implicated for alternative polyadenylation site choice, was co-purified with Thoc5, a component of human THO/TREX. Microarray analysis using human HeLa cells reveals knockdown of Thoc5 affects the expression of a subset of non-heat sho...
ORGANISM(S): Homo sapiens 
2013-05-21 | GSE42327 | GEO
GenomicsHomo sapiens
Illumina sequencing of CFIm68 binding regions in Hela cells
PRJDB2593 | ENA
UnknownDistinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade.
Not available
S-EPMC9458458 | biostudies-literature
GenomicsKnockdown of CFIm25 or CFIm68 decreases RNA polymerase II pausing and transcription
Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination and these steps are coordinated with co-transcriptional processing of the emerging pre-mRNA by capping, splicing, and cleavage and polyadenylation. Polyadenyla...
ORGANISM(S): Homo sapiens 
2019-06-20 | GSE99955 | GEO
GenomicsHomo sapiens
Genome-wide gene expression analysis in Thoc5- and CFIm68-depleted HeLa cells
PRJNA181059 | ENA
GenomicsDistinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade
Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade
PRJNA761713 | ENA
TranscriptomicsDistinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade
The precise maintenance of PTEN dosage is crucial for tumor suppression across a wide variety of cancers. Post-transcriptional regulation of Pten heavily relies on regulatory elements encoded by its 3’UTR. We previously reported the important diversity of 3’UTR isoforms of Pten mRNAs produced throug...
ORGANISM(S): Mus musculus 
2021-09-10 | GSE183704 | GEO
UnknownFXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA.
Not available
S-EPMC8863821 | biostudies-literature
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