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GenomicsExpression of cFLIP is necessary for diffuse large B cell lymphoma pathogenesis
Expression of cFLIP is necessary for diffuse large B cell lymphoma pathogenesis
PRJNA1430816 | ENA
GenomicsCRISPR screens for synthetic rescue of cFLIP depletion in primary effusion lymphoma cell lines
CRISPR screens for synthetic rescue of cFLIP depletion in primary effusion lymphoma cell lines
PRJNA865737 | ENA
UnknownReverse hierarchical DED assembly in the cFLIP-procaspase-8 and cFLIP-procaspase-8-FADD complexes.
Not available
S-EPMC11487272 | biostudies-literature
TranscriptomicsExpression of cFLIP is necessary for diffuse large B cell lymphoma pathogenesis
Diffuse large B cell lymphoma (DLBCL) is a highly heterogenous malignant disease that remains a major clinical challenge as relapsed and refractory disease is difficult to treat. Apoptosis evasion is a major feature of DLBCL. However, while the suppression of intrinsic apoptosis has long been recogn...
ORGANISM(S): Homo sapiens 
2026-03-15 | GSE322653 | GEO
UnknownFLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP.
Not available
S-EPMC4691174 | biostudies-literature
GenomicsMETTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium
METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium
PRJNA1090958 | ENA
GenomicscFLIP suppresses Caspase-1- and MLKL-independent perinatal lethality driven by autoprocessing impaired caspase-8 D387A
cFLIP suppresses Caspase-1- and MLKL-independent perinatal lethality driven by autoprocessing impaired caspase-8 D387A
PRJNA1275685 | ENA
UnknownAn engineered construct of cFLIP provides insight into DED1 structure and interactions.
Not available
S-EPMC8818036 | biostudies-literature
OtherCRISPR screens for synthetic rescue of cFLIP depletion in primary effusion lymphoma cell lines
Kaposi’s sarcoma-associated herpesvirus (KSHV) causes the B cell malignancy primary effusion lymphoma (PEL). We have previously shown that cultured PEL cell lines require expression of the cellular FLICE inhibitory protein (cFLIP) for survival (Manzano et al., Nat Comm 2018), although KSHV encodes a...
ORGANISM(S): Homo sapiens 
2022-08-10 | GSE210445 | GEO
UnknownHuR inhibition overcomes cFLIP-mediated doxorubicin resistance in triple-negative breast cancer.
Not available
S-EPMC11661992 | biostudies-literature
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