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TranscriptomicsInvestigation of molecular features involved in clinical responses and survival in advanced endometrial carcinoma
Hormone therapy (HT) is an effective treatment for metastatic endometrial carcinoma (mEC), with limited toxicity and low cost. We focused on molecular analysis of mECs treated by HT and, for the first time to date, we compared genomic profiles of paired metastasis and primary ECs. The main objective...
ORGANISM(S): Homo sapiens 
2022-03-16 | E-MTAB-11552 | biostudies-arrayexpress
TranscriptomicsProspective high-throughput genome profiling by comparative genomic hybridization (CGH) in advanced cancers.
We conducted a prospective monocenter clinical trial called PERMED01 to evaluate the number patients with locally advanced or metastatic cancer for whom identification of molecular alterations in tumor samples could lead to the delivery of a targeted therapy. Patients accessible to tumor biopsy were...
ORGANISM(S): Homo sapiens 
2021-03-01 | E-MTAB-9998 | biostudies-arrayexpress
TranscriptomicsGenome profiling of pancreatic adenocarcinoma
Pancreatic adenocarcinoma is one of the most aggressive human cancers and displays many different chromosomal abnormalities and mutations. By using 244K high-resolution array-comparative genomic hybridization (aCGH) we studied the genome alterations of 39 fine-needle aspirations from pancreatic aden...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-MTAB-570 | biostudies-arrayexpress
TranscriptomicsCandidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling
To better understand Luminal B subtype we studied in 188 breast cancers of various molecular subtypes, DNA copy number aberrations (CNAs), DNA promoter methylation and gene expression profiles. Please note mRNA expression data already submitted for study: E-GEOD-21653.
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1861 | biostudies-arrayexpress
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