Chagas disease - OmicsDI

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Organisms

Trypanosoma cruzi (25)
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Triatoma infestans (2)
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Trypanosoma cruzi M6241 cl.6 (1)
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Trypanosoma cruzi ATCC 30160 (1)
Trypanosoma rangeli Choachi (1)
Trypanosoma rangeli SC58 (1)
Rhodococcus rhodnii LMG 5362 (1)
134013 (1)
134006 (1)
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Heart (1)
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Disease

Chagas disease (29)
Trypanosomiasis (3)
Colorectal cancer,inflammatory bowel disease,Diverticular disease,Chagas Disease,Fournier Syndrome,Perineal trauma abdominoperineal,Ostomy (1)
Alzheimer's disease 1 (1)
Cartilage disease (1)
Chronic myeloid leukemia (1)
Disease free (1)
Pancreas adenocarcinoma (1)

Technology Type

Mass Spectrometry (59)
Shotgun proteomics (37)
Bottom-up proteomics (12)
Data-dependent acquisition (10)
Gel-based experiment (8)
Mass spectrometry (4)
Affinity purification coupled with mass spectrometry proteomics (3)
Top-down proteomics (2)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
Data-independent acquisition (1)
SRM/MRM (1)

Instrument Platform

Q Exactive Plus (17)
LTQ Orbitrap XL ETD (4)
LTQ Orbitrap Elite (2)
InnoScan 900 (1)
Illumina HiSeq 2000 (1)
MicrOTOF-Q II (1)
Q-exactive plus (1)
LTQ Orbitrap XL (1)
LTQ XL (1)
Orbitrap Fusion (1)
Q Exactive (1)
Q-Exactive HF mass spectrometer (1)
Liquid Chromatography MS - Alternating (LC-MS (Alternating)) (1)
Exactive (Thermo Scientific) (1)
Liquid Chromatography MS - positive (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - positive - hilic (1)

Publication Date

2020 (16)
2024 (15)
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2021 (14)
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2011 (10)
2019 (10)
2025 (8)
2005 (7)
2018 (6)
2010 (4)
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2012 (3)
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2014 (2)
2008 (2)
2016 (2)
2017 (1)

CHEBI ID

CHEBI:145104 (1)
CHEBI:145103 (1)
CHEBI:145102 (1)
CHEBI:145101 (1)
CHEBI:145100 (1)
CHEBI:145098 (1)
CHEBI:145099 (1)
CHEBI:145097 (1)
CHEBI:145095 (1)
CHEBI:145093 (1)
CHEBI:145092 (1)
CHEBI:80897 (1)
CHEBI:139424 (1)
CHEBI:145096 (1)
CHEBI:75839 (1)
CHEBI:65751 (1)
CHEBI:48294 (1)
CHEBI:80944 (1)
CHEBI:69814 (1)
CHEBI:66395 (1)
CHEBI:141136 (1)
CHEBI:145094 (1)
CHEBI:28157 (1)
CHEBI:16796 (1)
CHEBI:69657 (1)
CHEBI:27440 (1)
CHEBI:5262 (1)
CHEBI:5995 (1)
CHEBI:520 (1)
CHEBI:16860 (1)

Metabolite Name

15-hydroxy-eremantholide B (1)
Viguilenin (1)
1b,2a-epoxy tagitinin C (1)
Flavonol 3-o-glycosylated (1)
Pinocembrin (1)
2-oxo-8b-methacryloyloxy-guaia-3,10(14),11(13)-trien-6a,12-olide (1)
Galangin (1)
Genkwanin (1)
3,4',5-trihydroxy-7-methoxyflavone (1)
15-hydroxy-eremantholide b (1)
Hispidulin (1)
3,4,5-tri-O-E-caffeoylquinic acid (1)
Hirsutinolide (1)
3-O-caffeoyl-2-(2-butyl)-2-hydroxybutanedioic acid (1)
Budlein B (1)
4,5-di-O-E-caffeoylquinic acid (1)
3,4-di-O-E-caffeoylquinic acid (1)
Apigenin-7-O-glucoside (1)
Spiraeoside (1)
3,5-di-O-E-caffeoylquinic acid (1)
3-O-caffeoyl-2-(2-propyl)-2-hydroxybutanedioic acid (1)
1,5-di-O-E-caffeoylquinic acid (1)
Kaempferol-3-O-rutinoside (1)
Kaempferol-3-O-glucoside (1)
Quercetin-3-O-glucoronoside (1)
Quercetin-3-O-arabino-rhamnoside (1)
Luteolin-7-O-glucoside (1)
Methyl 5-O-E-caffeoylquinate (1)
5-O-E-feruloylquinic acid (1)
4-O-caffeoyl-2-C-methyl-D-erythronic acid (1)

First Public Date

2026 (19)
2021 (19)
2020 (17)
2014 (17)
2025 (16)
2022 (16)
2013 (12)
2024 (9)
2019 (9)
2017 (8)
2015 (8)
2023 (7)
2018 (5)
2016 (5)
2012 (1)
2011 (1)

Modelling Approach

Constraint-based model (1)

Study status

Active, not recruiting (1)

Lab affiliation

Instituto de Biotecnología, Grupo de Bioquímica y Parasitología Molecular, Departamento de Parasitología, Universidad de Granada, Granada, Spain. (6)
Proteomic Platform, Laboratory of Molecular Parasitology, Université Libre de Bruxelles, Belgium (2)
1Laboratory of Vector-Pathogen Biology, Proteomic Platform, Departmet of Molecular Biology, Université Libre de Bruxelles (1)
Aix-Marseille univ, CNRS, Inserm, Institut Paoli-Calmettes, CRCM, Marseille Protéomique (1)
Biological Chemistry and Drug Discovery University of Dundee (1)
Biological Sciences, The University of Texas at El Paso (1)
Carlos Chagas Institute, Fiocruz Parana, Brazil (1)
Centro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador (1)
Chair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany (1)
Departamento de Bioquímica Instituto de Química, Universidade de São Paulo, São Paulo, São Paulo, Brazil. (1)
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil (1)
Departamento de Ciências Biológicas, Laboratório de Enzimologia e Proteômica, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Brasil (1)
Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA (1)
Department of Medicine, McGill University, Montreal, Quebec, Canada (1)
Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo (1)
Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Lineu Prestes 1374, Room 9, Butanta, Sao Paulo (1)
Departmento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil (1)
Dept. of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. (1)
EVAHPI Research Group, Laboratório de Biologia Celular, Instituto Carlos Chagas, Fundação Oswaldo Cruz (1)
Evandro Chagas National Institute of Infectious Diseases (INI), Oswal1Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.do Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. (1)
Federal University of Rio de Janeiro (1)
Functional Genomics Laboratory, Carlos Chagas Institute, Fiocruz, Curitiba, Parana, Brazil (1)
GlycoProteomics Laboratory, Department of Parasitology, ICB, University of São Paulo, Sao Paulo, Brazil (1)
Glycoproteomics Lab. Department of Parasitology Institute of Biomedical Sciences - University of São Paulo (1)
Glycoproteomics Laboratory, Department of Parasitology, Institute of Biomedical Sciences, Universidade of Sao Paulo (1)
Host-Pathogen Interface Laboratory (1)
INSERM U1212, Institut Européen de Chimie et Biologie, University of Bordeaux, Pessac 33607, France (1)
Immunopathology Laboratory Biological Sciences Research Center Federal University of Ouro Preto (UFOP) (1)
Institut Européen de Chimie et Biologie (IECB), U1212 Inserm, Université de Bordeaux, 2 rue R. Escarpit, F-33600 Pessac, France (1)
Instituto Carlos Chagas, FIOCRUZ Parana (1)

IsPrivate

False (1)

Submitter Keywords

FROG (1)

Classification

protozoa (30)

Study type

Transcription profiling by array (16)
Antigen profiling (4)
Unknown experiment type (1)
Comparative genomic hybridization by array (1)
RNA-seq of coding RNA (1)
Interventional (1)

Release Date

2021 (344)
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2023 (301)
2025 (271)
2020 (247)
2018 (244)
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2019 (209)
2017 (194)
2015 (139)
2016 (129)
2014 (128)
2013 (86)
2012 (66)
2011 (58)
2010 (45)
2026 (43)
2009 (29)
2008 (21)
2005 (15)
2007 (15)
2006 (9)
2000 (5)
2004 (4)
2003 (4)
2002 (4)
2001 (4)
1999 (1)
1998 (1)

Location

Brazil (1)

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Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease

Chagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory resp...

2024-01-11 | MTBLS8390 | MetaboLights

The Trypanosoma cruzi Antigen and Epitope Atlas: fine characterization of antibody specificities in human Chagas Disease patients across human populations

These assays represent antibody-binding assays to analyze seroprevalence of antigens and epitopes at the individual level and also to perform fine epitope mapping characterizations. In this screening 392,299 peptides derived from reactive (antigenic) regions of Trypanosoma cruzi proteins were displa...

ORGANISM(S): Homo sapiens

2022-08-20 | E-MTAB-11655 | biostudies-arrayexpress

Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas’ disease drug discovery

Chagas’ disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is a potentially fatal condition for which new treatments are urgently needed. Due to the lack of validated drug targets, phenotypic screening followed by target deconvolution is the dominant approach in Chagas’ d...

2026-01-12 | MTBLS13510 | MetaboLights

The Trypanosoma cruzi Antigen and Epitope Atlas: discovery of antibody specificities in human Chagas Disease patients across human populations

These assays represent an antigen discovery screening, and epitope mapping characterization. In this screening two complete proteomes from Trypanosoma cruzi, from two different strains (CL-Brener, Sylvio X10), were displayed in the form of short peptides (tiling array, overlapped) and assayed with p...

ORGANISM(S): Homo sapiens

2022-08-20 | E-MTAB-11651 | biostudies-arrayexpress

High-throughput discovery of Chagas Disease antigens and their linear B-cell epitopes using high-density peptide arrays

Screening of antibody-binding specificities from pooled normal (healthy) and chronic Chagas Disease patients.

ORGANISM(S): Homo sapiens

2015-06-24 | E-MTAB-3008 | biostudies-arrayexpress

The Trypanosoma cruzi Antigen and Epitope Atlas: changes in antibody levels over time in Chagas disease patients from the E1224 clinical study

These assays analyze the dynamics of the antibody responses in selected Chagas disease patients from the E1224 clinical trial (ClinicalTrials.gov ID: NCT01489228). The assays measure specific antibody-binding to 392,299 short peptides derived from Trypanosoma cruzi, spanning antigenic regions and ep...

ORGANISM(S): Homo sapiens

2026-07-10 | E-MTAB-17293 | biostudies-arrayexpress

Trypanosomatid extracellular vesicles as potential immunogens in Chagas disease

Extracellular vesicles (EVs) from parasite protozoa can induce efficient immunity, which makes them useful for probable next-generation vaccines, more specifically against Trypanosoma cruzi infection. Howevver, the mechanisms involved in the protective responses have not been fully elucidated. To in...

ORGANISM(S): Trypanosoma rangeli Phytomonas serpens Trypanosoma cruzi Dm28c

2025-01-21 | PXD040019 | Pride

Discovery of potential biomarkers in plasma-derived extracellular vesicles of a heart-transplanted chronic Chagas disease patient

Chagas disease (CD) is emerging in nonendemic countries. Biomarkers for earlier therapeutic response assessment in chronic CD patients are much needed. Here, we describe the first proteomic profiling of plasma-derived extracellular vesicles from a heart-transplanted patient with chronic CD and show ...

ORGANISM(S): Trypanosoma cruzi Homo sapiens (Human)

2021-09-08 | PXD014668 | Pride

Proteomic analysis Extracellular vesicles Chagas disease Biomarkers Trypanosoma

Transcriptome analysis of circulating microRNAs associated with Chagas disease susceptibility and chronic Chagas cardiomyopathy severity

PRJNA1275016 | ENA

Chagas disease.

Not available

S-EPMC2653922 | biostudies-literature

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