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TranscriptomicsGene expression analysis of estrogen receptor mutants, S463P, Y537S and D538G in MCF7 cells
Analysis of MCF7 cells transfected with ER mutants (S463P, Y537S and D538G) in phenol-red free, charcoal stripped FBS media and regular DMEM/F12 media. Results provide insight on the gene expression profiles induced by the various ER mutants. Total RNA extracted from transfected cells 48 hours after...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51448 | biostudies-arrayexpress
UnknownSystemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology clinical practice guideline.

Purpose

To provide evidence-based recommendations to practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2) -positive advanced breast cancer.

Methods

The American Society of Clinical Oncology convened a panel of medical ...
S-EPMC6076031 | biostudies-literature
UnknownAKT Inhibition in Solid Tumors With AKT1 Mutations.
Purpose AKT1 E17K mutations are oncogenic and occur in many cancers at a low prevalence. We performed a multihistology basket study of AZD5363, an ATP-competitive pan-AKT kinase inhibitor, to determine the preliminary activity of AKT inhibition in AKT-mutant cancers. Patients and Methods Fifty-eight...
S-EPMC5501365 | biostudies-literature
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