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ProteomicsMitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite
L-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals, due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), which oxidizes L-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulation. In humans lacking L2HGDH activity, L-2-HG builds up, leading to L-2-HG aciduria, a rare c...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-31 | PXD054020 | Pride
Mitochondria Metabolism 2-og-dependent dioxygenases Metabolite signaling Gene expression regulation 
ProteomicsER -associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
Mass spectrometry characterization of the proteins in complex with endogenous HRD1 yielded a total of 347 proteins from three independent experiments
ORGANISM(S): Homo Sapiens 
2018-04-04 | PXD009402 |
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