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TranscriptomicsReplication-Timing Boundaries Facilitate Cell-type and Species-specific Regulation of a Rearranged Human Chromosome in Mouse
In multicellular organisms, developmental changes to replication timing occur in 400- 800 kb domains across half the genome. While clear examples of epigenetic control of replication timing have been described, a role for DNA sequence in mammalian replication timing has not been substantiated. To...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-38472 | biostudies-arrayexpress
TranscriptomicsIndependence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation
The expansion of repressive epigenetic marks has been implicated in heterochromatin formation during embryonic development, but the general applicability of this mechanism is unclear. Here we show that nuclear rearrangement of repressive histone marks H3K9me3 and H3K27me3 into non-overlapping struct...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-38460 | biostudies-arrayexpress
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