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MetabolomicsHyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment

Introduction

Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated w...
2022-02-07 | MTBLS2150 | MetaboLights
MetabolomicsMetabolomics Characterization of Human Calcific Aortic Valve Stenosis

BACKGROUND: Calcific aortic valve stenosis (CAVS) is the most prevalent valvular heart disease in developed countries with significant morbidity and mortality. Given the poor understanding of the pathophysiological processes leading to CAVS, we utilized a joint non-targeted metab...

2020-02-03 | MTBLS1267 | MetaboLights
MetabolomicsEFO: In preparation - Early Metabolic Predictors of Type 2 Diabetes Mellitus in Normoglycemic Adults: Insights from Six-Year Prospective Cohort Study

INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often preceded by latent metabolic disruptions. Early detection of metabolic alterations can facilitate timely intervention to delay or prevent T2DM onset. Metaboli...

2025-08-04 | MTBLS10965 | MetaboLights
ProteomicsProtein profiling of Aortic-Valvular and Endocardial endothelial cells using label-free proteomics
The variations in the protein profile of aortic-valvular (AVE) and endocardial endothelial (EE) cells are currently unknown. The current study's objective is to identify differentially expressed proteins and associated pathways in both endothelial cells. We used endothelial cells isolated from the p...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD025922 | Pride
Endocardial endothelial (ee) cells Aortic-valvular (ave) Lc-ms/ms 
MetabolomicsPostprandial Metabolism is Impaired in Overweight Normoglycemic Young Adults without Family History of Diabetes

While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of transition from normal to a prediabetes state are unidentified. We studied the basal metabolism and metabolic response to a mixed-meal challenge in 110 healthy subjects in the age group of 18 to 40 years (Mal...

2019-03-14 | MTBLS743 | MetaboLights
UnknownProteomics Analysis Reveals Diverse Molecular Characteristics between Endocardial and Aortic-Valvular Endothelium.
Not available
S-EPMC8304717 | biostudies-literature
TranscriptomicsSingle-cell transcriptome and T cell receptor profiling of the tuberculin skin test
We undertook single cell RNA, TCR and antibody-derived tag (ADT) sequencing of human skin suction blisters induced at the site of of the tuberculin skin test on day 2. This submission comprises data from 31 individuals (9 male, 22 female) with immunological memory to mycobacterial antigens. TotalSeq...
ORGANISM(S): Homo sapiens 
2026-07-09 | E-MTAB-14246 | biostudies-arrayexpress
ModelsDvarak2020 - PXR targeting using microbial metabolite mimicry
this is a model in the PDB format.
2020-04-03 | MODEL2002050001 | BioModels
UnknownTargeting the Pregnane X Receptor Using Microbial Metabolite Mimicry
Not available
S-SCDT-EMM-2019-11621-T | biostudies-other
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